BNC-210 | CAS# 1020634-41-6 | Biochemical

MedKoo Cat#: 576822 | Name: BNC-210 TFA

Description:

WARNING: This product is for research use only, not for human or veterinary use.

BNC210, also known as IW-2143, is an anxiolytic drug that acts via negative allosteric modulation of the α7-nicotinic acetylcholine receptor. It is currently being investigated for the treatment of post traumatic stress disorder. The drug has demonstrated clinically significant anxiety reduction in both animal models and in Phase I trials.

Chemical Structure

BNC-210 TFA

CAS#160448-56-6 (TFA)

Theoretical Analysis

MedKoo Cat#: 576822

Name: BNC-210 TFA

CAS#: 160448-56-6 (TFA)

Chemical Formula: C19H24F3N3O5

Exact Mass: 0.0000

Molecular Weight: 431.41

Elemental Analysis: C, 52.90; H, 5.61; F, 13.21; N, 9.74; O, 18.54

Price and Availability

This product was removed for the commercial reasons.

Related CAS #

1020634-41-6 (deleted) 13589-06-5 (free base) 160448-56-6 (TFA)

Synonym

BNC-210; BNC 210; BNC210; IW-2143; IW 2143; IW2143

IUPAC/Chemical Name

(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid trifluoroacetic acid

InChi Key

GIOABCXJJDQJDM-QXGXBFBTSA-N

InChi Code

InChI=1S/C17H23N3O3.C2HF3O2/c1-3-10(2)15(18)16(21)20-14(17(22)23)8-11-9-19-13-7-5-4-6-12(11)13;3-2(4,5)1(6)7/h4-7,9-10,14-15,19H,3,8,18H2,1-2H3,(H,20,21)(H,22,23);(H,6,7)/t10-,14-,15-;/m0./s1

SMILES Code

O=C(O)[C@@H](NC([C@@H](N)[C@@H](C)CC)=O)CC1=CNC2=C1C=CC=C2.O=C(O)C(F)(F)F

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 431.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1. Chan D. AIMECS 09--Seventh AFMC International Medicinal Chemistry Congress. 23-27 August 2009, Cairns, Queensland, Australia. IDrugs. 2009 Oct;12(10):614-6. PMID: 19790007.