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MedKoo Cat#: 145205 | Name: Dinoxyline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dinoxyline is a D(1) receptor agonist. DINOXYLINE has a conformationally rigid structure. Dinoxyline is also a potential bioisostere.

Chemical Structure

Dinoxyline
Dinoxyline
CAS#757176-96-8

Theoretical Analysis

MedKoo Cat#: 145205

Name: Dinoxyline

CAS#: 757176-96-8

Chemical Formula: C15H13NO3

Exact Mass: 255.0895

Molecular Weight: 255.27

Elemental Analysis: C, 70.58; H, 5.13; N, 5.49; O, 18.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Dinoxyline;
IUPAC/Chemical Name
1,2,3,11b-tetrahydrochromeno[4,3,2-de]isoquinoline-8,9-diol
InChi Key
QOHSTVKJXZTEOL-UHFFFAOYSA-N
InChi Code
1S/C15H13NO3/c17-11-5-4-9-10-7-16-6-8-2-1-3-12(13(8)10)19-15(9)14(11)18/h1-5,10,16-18H,6-7H2
SMILES Code
OC1=CC=C2C3CNCC4=CC=CC(OC2=C1O)=C34
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 255.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhang J, Xiong B, Zhen X, Zhang A. Dopamine D1 receptor ligands: where are we now and where are we going. Med Res Rev. 2009 Mar;29(2):272-94. doi: 10.1002/med.20130. PMID: 18642350. 2: Grubbs RA, Lewis MM, Owens-Vance C, Gay EA, Jassen AK, Mailman RB, Nichols DE. 8,9-dihydroxy-1,2,3,11b-tetrahydrochromeno[4,3,2,-de]isoquinoline (dinoxyline), a high affinity and potent agonist at all dopamine receptor isoforms. Bioorg Med Chem. 2004 Mar 15;12(6):1403-12. doi: 10.1016/j.bmc.2004.01.008. PMID: 15018913. 3: Ryman-Rasmussen JP, Nichols DE, Mailman RB. Differential activation of adenylate cyclase and receptor internalization by novel dopamine D1 receptor agonists. Mol Pharmacol. 2005 Oct;68(4):1039-48. doi: 10.1124/mol.105.012153. Epub 2005 Jun 28. PMID: 15985612. 4: Fowler JC, Bhattacharya S, Urban JD, Vaidehi N, Mailman RB. Receptor conformations involved in dopamine D(2L) receptor functional selectivity induced by selected transmembrane-5 serine mutations. Mol Pharmacol. 2012 Jun;81(6):820-31. doi: 10.1124/mol.111.075457. Epub 2012 Mar 13. PMID: 22416052; PMCID: PMC3362898. 5: Gay EA, Urban JD, Nichols DE, Oxford GS, Mailman RB. Functional selectivity of D2 receptor ligands in a Chinese hamster ovary hD2L cell line: evidence for induction of ligand-specific receptor states. Mol Pharmacol. 2004 Jul;66(1):97-105. doi: 10.1124/mol.66.1.97. PMID: 15213300.