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MedKoo Cat#: 413978 | Name: DX-9065 Free Base

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DX-9065 Free Base is a biochemical

Chemical Structure

DX-9065 Free Base
DX-9065 Free Base
CAS#150612-55-8 (free base)

Theoretical Analysis

MedKoo Cat#: 413978

Name: DX-9065 Free Base

CAS#: 150612-55-8 (free base)

Chemical Formula: C26H28N4O3

Exact Mass: 444.2161

Molecular Weight: 444.54

Elemental Analysis: C, 70.25; H, 6.35; N, 12.60; O, 10.80

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
150611-80-6 (HCl) 150612-55-8 (free base)
Synonym
DX-9065 Free Base; DX9065; DX 9065
IUPAC/Chemical Name
(alphaS)-7-(Aminoiminomethyl)-alpha-(4-(((3S)-1-(1-iminoethyl)-3-pyrrolidinyl)oxy)phenyl)-2-naphthalenepropanoic acid
InChi Key
AGRCGQSFFMCBRE-ZEQRLZLVSA-N
InChi Code
InChI=1S/C26H28N4O3/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32)/t23-,24-/m0/s1
SMILES Code
O=C(O)[C@H](C1=CC=C(O[C@@H]2CN(C(C)=N)CC2)C=C1)CC3=CC=C4C=CC(C(N)=N)=CC4=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 444.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fujii Y, Kanamaru T, Kikuchi H, Yamashita S, Sakuma S. Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant. Eur J Pharm Sci. 2011 Mar 18;42(4):392-9. doi: 10.1016/j.ejps.2011.01.003. Epub 2011 Jan 14. PMID: 21238588. 2: Fujii Y, Takahashi M, Ishiguro T, Sakuma S, Uekama K, Irie T. Cyclodextrins improve oral absorption of a novel factor Xa inhibitor by interfering with interaction between the drug and bile acids in rats. J Pharm Pharmacol. 2013 Nov;65(11):1598-606. doi: 10.1111/jphp.12137. Epub 2013 Sep 5. PMID: 24118066. 3: Fujii Y, Kanamaru T, Kikuchi H, Nakagami H, Yamashita S, Akashi M, Sakuma S. Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form. Int J Pharm. 2011 Dec 15;421(2):244-51. doi: 10.1016/j.ijpharm.2011.09.046. Epub 2011 Oct 5. PMID: 22001539. 4: Kaiser B. DX-9065a, a direct inhibitor of factor Xa. Cardiovasc Drug Rev. 2003 Summer;21(2):91-104. doi: 10.1111/j.1527-3466.2003.tb00108.x. PMID: 12847561. 5: Murayama N, McMahon H, Young CG, McCracken NW, Okamura Y, Hakusui H, Tanaka M. Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose. Xenobiotica. 2000 May;30(5):515-21. doi: 10.1080/004982500237514. PMID: 10875684. 6: Kaiser B. DX-9065a Daiichi. Curr Opin Investig Drugs. 2003 Sep;4(9):1105-12. PMID: 14582456. 7: Matsushita K, Imamura T, Tomikawa M, Tancharoen S, Tatsuyama S, Maruyama I. DX-9065a inhibits proinflammatory events induced by gingipains and factor Xa. J Periodontal Res. 2006 Apr;41(2):148-56. doi: 10.1111/j.1600-0765.2005.00853.x. PMID: 16499718. 8: Herbert JM, Bernat A, Dol F, Hérault JP, Crépon B, Lormeau JC. DX 9065A a novel, synthetic, selective and orally active inhibitor of factor Xa: in vitro and in vivo studies. J Pharmacol Exp Ther. 1996 Mar;276(3):1030-8. PMID: 8786532. 9: Hara T, Yokoyama A, Ishihara H, Yokoyama Y, Nagahara T, Iwamoto M. DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa. Thromb Haemost. 1994 Mar;71(3):314-9. PMID: 8029795. 10: Fujii Y, Takahashi M, Morita H, Kikuchi H, Aramaki Y, Amidon GL. Characteristics of gastrointestinal absorption of DX-9065a, a new synthetic anticoagulant. Drug Metab Pharmacokinet. 2007 Feb 25;22(1):26-32. doi: 10.2133/dmpk.22.26. PMID: 17329908.

View History

Evernitrose, L-

Evernitrose, L-