DX-9065 HCl | CAS# 150611-80-6 (HCl)

MedKoo Cat#: 413977 | Name: DX-9065 HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

DX-9065 HCl is a biochemical

Chemical Structure

DX-9065 HCl

CAS#150611-80-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 413977

Name: DX-9065 HCl

CAS#: 150611-80-6 (HCl)

Chemical Formula: C26H29ClN4O3

Exact Mass:

Molecular Weight: 480.99

Elemental Analysis: C, 64.93; H, 6.08; Cl, 7.37; N, 11.65; O, 9.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

150611-80-6 (HCl) 150612-55-8 (free base)

Synonym

DX-9065 HCl; DX9065 hydrochloride; DX 9065 hydrochloride; DX-9065 hydrochloride

IUPAC/Chemical Name

2-Naphthalenepropanoic acid, 7-(aminoiminomethyl)-alpha-(4-(((3S)-1-(1-iminoethyl)-3-pyrrolidinyl)oxy)phenyl)-, monohydrochloride, (alphaS)-

InChi Key

MQAQKHCMPMBWIS-UKOKCHKQSA-N

InChi Code

InChI=1S/C26H28N4O3.ClH/c1-16(27)30-11-10-23(15-30)33-22-8-6-19(7-9-22)24(26(31)32)13-17-2-3-18-4-5-20(25(28)29)14-21(18)12-17;/h2-9,12,14,23-24,27H,10-11,13,15H2,1H3,(H3,28,29)(H,31,32);1H/t23-,24-;/m0./s1

SMILES Code

O=C(O)[C@H](C1=CC=C(O[C@@H]2CN(C(C)=N)CC2)C=C1)CC3=CC=C4C=CC(C(N)=N)=CC4=C3.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 480.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fujii Y, Kanamaru T, Kikuchi H, Yamashita S, Sakuma S. Enteric-coated tablets improve oral bioavailability of DX-9065, a novel anticoagulant. Eur J Pharm Sci. 2011 Mar 18;42(4):392-9. doi: 10.1016/j.ejps.2011.01.003. Epub 2011 Jan 14. PMID: 21238588. 2: Fujii Y, Takahashi M, Ishiguro T, Sakuma S, Uekama K, Irie T. Cyclodextrins improve oral absorption of a novel factor Xa inhibitor by interfering with interaction between the drug and bile acids in rats. J Pharm Pharmacol. 2013 Nov;65(11):1598-606. doi: 10.1111/jphp.12137. Epub 2013 Sep 5. PMID: 24118066. 3: Fujii Y, Kanamaru T, Kikuchi H, Nakagami H, Yamashita S, Akashi M, Sakuma S. Improvement of low bioavailability of a novel factor Xa inhibitor through formulation of cationic additives in its oral dosage form. Int J Pharm. 2011 Dec 15;421(2):244-51. doi: 10.1016/j.ijpharm.2011.09.046. Epub 2011 Oct 5. PMID: 22001539. 4: Kaiser B. DX-9065a, a direct inhibitor of factor Xa. Cardiovasc Drug Rev. 2003 Summer;21(2):91-104. doi: 10.1111/j.1527-3466.2003.tb00108.x. PMID: 12847561. 5: Murayama N, McMahon H, Young CG, McCracken NW, Okamura Y, Hakusui H, Tanaka M. Pharmacokinetics of the anticoagulant 14C-DX-9065a in the healthy male volunteer after a single intravenous dose. Xenobiotica. 2000 May;30(5):515-21. doi: 10.1080/004982500237514. PMID: 10875684. 6: Kaiser B. DX-9065a Daiichi. Curr Opin Investig Drugs. 2003 Sep;4(9):1105-12. PMID: 14582456. 7: Matsushita K, Imamura T, Tomikawa M, Tancharoen S, Tatsuyama S, Maruyama I. DX-9065a inhibits proinflammatory events induced by gingipains and factor Xa. J Periodontal Res. 2006 Apr;41(2):148-56. doi: 10.1111/j.1600-0765.2005.00853.x. PMID: 16499718. 8: Herbert JM, Bernat A, Dol F, Hérault JP, Crépon B, Lormeau JC. DX 9065A a novel, synthetic, selective and orally active inhibitor of factor Xa: in vitro and in vivo studies. J Pharmacol Exp Ther. 1996 Mar;276(3):1030-8. PMID: 8786532. 9: Hara T, Yokoyama A, Ishihara H, Yokoyama Y, Nagahara T, Iwamoto M. DX-9065a, a new synthetic, potent anticoagulant and selective inhibitor for factor Xa. Thromb Haemost. 1994 Mar;71(3):314-9. PMID: 8029795. 10: Fujii Y, Takahashi M, Morita H, Kikuchi H, Aramaki Y, Amidon GL. Characteristics of gastrointestinal absorption of DX-9065a, a new synthetic anticoagulant. Drug Metab Pharmacokinet. 2007 Feb 25;22(1):26-32. doi: 10.2133/dmpk.22.26. PMID: 17329908.