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MedKoo Cat#: 413954 | Name: Dubermatinib tartrate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dubermatinib tartrate is an Antineoplastic

Chemical Structure

Dubermatinib tartrate
Dubermatinib tartrate
CAS#2305089-34-1 (tartrate)

Theoretical Analysis

MedKoo Cat#: 413954

Name: Dubermatinib tartrate

CAS#: 2305089-34-1 (tartrate)

Chemical Formula: C32H42ClN7O14S

Exact Mass: 815.2199

Molecular Weight: 816.23

Elemental Analysis: C, 47.09; H, 5.19; Cl, 4.34; N, 12.01; O, 27.44; S, 3.93

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
2305089-34-1 (tartrate) 1341200-45-0 (free base)
Synonym
Dubermatinib tartrate; TP0903 tartrate; TP 0903 tartrate; TP-0903 tartrate
IUPAC/Chemical Name
Benzenesulfonamide, 2-((5-chloro-2-((4-((4-methyl-1-piperazinyl)methyl)phenyl)amino)-4-pyrimidinyl)amino)-N,N-dimethyl-, (2R,3R)-2,3-dihydroxybutanedioate (1:2)
InChi Key
ITRNHQKFTJNXTE-WBPXWQEISA-N
InChi Code
InChI=1S/C24H30ClN7O2S.2C4H6O6/c1-30(2)35(33,34)22-7-5-4-6-21(22)28-23-20(25)16-26-24(29-23)27-19-10-8-18(9-11-19)17-32-14-12-31(3)13-15-32;2*5-1(3(7)8)2(6)4(9)10/h4-11,16H,12-15,17H2,1-3H3,(H2,26,27,28,29);2*1-2,5-6H,(H,7,8)(H,9,10)/t;2*1-,2-/m.11/s1
SMILES Code
O=S(C1=CC=CC=C1NC2=NC(NC3=CC=C(CN4CCN(C)CC4)C=C3)=NC=C2Cl)(N(C)C)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O.O=C(O)[C@H](O)[C@@H](O)C(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 816.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Park IK, Mundy-Bosse B, Whitman SP, Zhang X, Warner SL, Bearss DJ, Blum W, Marcucci G, Caligiuri MA. Receptor tyrosine kinase Axl is required for resistance of leukemic cells to FLT3-targeted therapy in acute myeloid leukemia. Leukemia. 2015 Jun 19. doi: 10.1038/leu.2015.147. [Epub ahead of print] PubMed PMID: 26172401. 2: Sinha S, Boysen J, Nelson M, Secreto C, Warner SL, Bearss DJ, Lesnick C, Shanafelt TD, Kay NE, Ghosh AK. Targeted Axl Inhibition Primes Chronic Lymphocytic Leukemia B Cells to Apoptosis and Shows Synergistic/Additive Effects in Combination with BTK Inhibitors. Clin Cancer Res. 2015 May 1;21(9):2115-26. doi: 10.1158/1078-0432.CCR-14-1892. Epub 2015 Feb 11. PubMed PMID: 25673699; PubMed Central PMCID: PMC4479154.