JF0049 | AKR1B10 inhibitor

MedKoo Cat#: 128315 | Name: JF0049

Description:

WARNING: This product is for research use only, not for human or veterinary use.

JF0049 is an AKR1B10 inhibitor.

Chemical Structure

JF0049

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128315

Name: JF0049

CAS#: N/A

Chemical Formula: C14H11Br3N2O5

Exact Mass: 523.8218

Molecular Weight: 526.96

Elemental Analysis: C, 31.91; H, 2.10; Br, 45.49; N, 5.32; O, 15.18

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

JF0049; JF 0049; JF-0049

IUPAC/Chemical Name

2-(2,4-dioxo-3-(3,4,5-tribromo-2-methoxybenzyl)-3,4-dihydropyrimidin-1(2H)-yl)acetic acid

InChi Key

IOWPTRWNPWHVBL-UHFFFAOYSA-N

InChi Code

InChI=1S/C14H11Br3N2O5/c1-24-13-7(4-8(15)11(16)12(13)17)5-19-9(20)2-3-18(14(19)23)6-10(21)22/h2-4H,5-6H2,1H3,(H,21,22)

SMILES Code

BrC1=C(OC)C(CN2C(N(CC(O)=O)C=CC2=O)=O)=CC(Br)=C1Br

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 526.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Ruiz FX, Cousido-Siah A, Porté S, Domínguez M, Crespo I, Rechlin C, Mitschler A, de Lera ÁR, Martín MJ, de la Fuente JÁ, Klebe G, Parés X, Farrés J, Podjarny A. Structural Determinants of the Selectivity of 3-Benzyluracil-1-acetic Acids toward Human Enzymes Aldose Reductase and AKR1B10. ChemMedChem. 2015 Dec;10(12):1989-2003. doi: 10.1002/cmdc.201500393. Epub 2015 Nov 9. PMID: 26549844.