Synonym
Dobutamine Free Base; Dobutamina; LY81929; LY-81929; LY 81929; (±)-Dobutamine; DL-Dobutamine; Racemic dobutamine;
IUPAC/Chemical Name
1,2-Benzenediol, 4-(2-((3-(4-hydroxyphenyl)-1-methylpropyl)amino)ethyl)-, (+-)-
InChi Key
JRWZLRBJNMZMFE-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H23NO3/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15/h4-9,12-13,19-22H,2-3,10-11H2,1H3
SMILES Code
OC1=CC=C(CCNC(C)CCC2=CC=C(O)C=C2)C=C1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
301.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Dubin A, Lattanzio B, Gatti L. The spectrum of cardiovascular effects of dobutamine - from healthy subjects to septic shock patients. Rev Bras Ter Intensiva. 2017 Oct-Dec;29(4):490-498. doi: 10.5935/0103-507X.20170068. PMID: 29340539; PMCID: PMC5764562.
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5: Mahoney L, Shah G, Crook D, Rojas-Anaya H, Rabe H. A Literature Review of the Pharmacokinetics and Pharmacodynamics of Dobutamine in Neonates. Pediatr Cardiol. 2016 Jan;37(1):14-23. doi: 10.1007/s00246-015-1263-9. Epub 2015 Sep 7. Erratum in: Pediatr Cardiol. 2016 Dec 1;: PMID: 26346024.
6: Mielgo V, Valls i Soler A, Rey-Santano C. Dobutamine in paediatric population: a systematic review in juvenile animal models. PLoS One. 2014 Apr 22;9(4):e95644. doi: 10.1371/journal.pone.0095644. PMID: 24755688; PMCID: PMC3995779.
7: Al Madfai F, Valah B, Zaidi STR, Wanandy T, Ming LC, Peterson GM, Patel RP. Stability of dobutamine in continuous ambulatory delivery devices. J Clin Pharm Ther. 2018 Aug;43(4):530-535. doi: 10.1111/jcpt.12674. Epub 2018 Mar 2. PMID: 29500838.
8: Madias JE. Pathophysiological insights from dobutamine-induced Takotsubo syndrome. Anatol J Cardiol. 2018 Aug;20(2):134. doi: 10.14744/AnatolJCardiol.2018.50708. PMID: 30088490; PMCID: PMC6237951.
9: Wislicki L. [Dobutamine]. Harefuah. 1979 Dec;97(11-12):312-3. Hebrew. PMID: 16296120.
10: Kittleson MD. Dobutamine. J Am Vet Med Assoc. 1980 Oct 1;177(7):642-3. PMID: 7440359.
