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MedKoo Cat#: 317631 | Name: Dobutamine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock. Its primary mechanism is direct stimulation of β1 receptors of the sympathetic nervous system.

Chemical Structure

Dobutamine HCl
Dobutamine HCl
CAS#49745-95-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 317631

Name: Dobutamine HCl

CAS#: 49745-95-1 (HCl)

Chemical Formula: C18H24ClNO3

Exact Mass: 0.0000

Molecular Weight: 337.84

Elemental Analysis: C, 63.99; H, 7.16; Cl, 10.49; N, 4.15; O, 14.21

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
50mg USD 550.00 2 Weeks
100mg USD 850.00 2 Weeks
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Related CAS #
34368-04-2 (free base) 101626-66-8 (tartrate) 104564-71-8 (lactobionate) 49745-95-1 (HCl) 120885-53-2 (phosphate)
Synonym
Dobutamine hydrochloride; Dobutamine HCl; Dobutrex; Inotrex; NSC 299583; NSC299583; NSC-299583
IUPAC/Chemical Name
4-(2-((4-(4-hydroxyphenyl)butan-2-yl)amino)ethyl)benzene-1,2-diol hydrochloride
InChi Key
BQKADKWNRWCIJL-UHFFFAOYSA-N
InChi Code
InChI=1S/C18H23NO3.ClH/c1-13(2-3-14-4-7-16(20)8-5-14)19-11-10-15-6-9-17(21)18(22)12-15;/h4-9,12-13,19-22H,2-3,10-11H2,1H3;1H
SMILES Code
OC1=CC=C(CCNC(CCC2=CC=C(O)C=C2)C)C=C1O.[H]Cl
Appearance
Grey solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, not in water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 337.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lv MY, Deng SL, Long XF. rhBNP therapy can improve clinical outcomes and reduce in-hospital mortality compared with dobutamine in heart failure patients: a meta-analysis. Br J Clin Pharmacol. 2016 Jan;81(1):174-85. doi: 10.1111/bcp.12788. Epub 2015 Nov 28. Review. PubMed PMID: 26382927; PubMed Central PMCID: PMC4693581. 2: Januszko-Giergielewicz B, Dębska-Ślizień A, Górny J, Kozak J, Oniszczuk K, Gromadziński L, Dorniak K, Dudziak M, Malinowski P, Rutkowski B. Dobutamine stress echocardiography in the diagnosis of asymptomatic ischemic heart disease in patients with chronic kidney disease--review of literature and single-center experience. Transplant Proc. 2015 Mar;47(2):295-303. doi: 10.1016/j.transproceed.2014.11.034. Review. PubMed PMID: 25769563. 3: Joyce E, Delgado V, Bax JJ, Marsan NA. Advanced techniques in dobutamine stress echocardiography: focus on myocardial deformation analysis. Heart. 2015 Jan;101(1):72-81. doi: 10.1136/heartjnl-2013-303850. Epub 2014 Apr 23. Review. PubMed PMID: 24760702. 4: Gupta S, Donn SM. Neonatal hypotension: dopamine or dobutamine? Semin Fetal Neonatal Med. 2014 Feb;19(1):54-9. doi: 10.1016/j.siny.2013.09.006. Epub 2013 Oct 5. Review. PubMed PMID: 24100169. 5: Mielgo V, Valls i Soler A, Rey-Santano C. Dobutamine in paediatric population: a systematic review in juvenile animal models. PLoS One. 2014 Apr 22;9(4):e95644. doi: 10.1371/journal.pone.0095644. eCollection 2014. Review. PubMed PMID: 24755688; PubMed Central PMCID: PMC3995779. 6: Nguyen P, Plotkin J, Fishbein TM, Laurin JM, Satoskar R, Shetty K, Taylor AJ. Dobutamine stress echocardiography in patients undergoing orthotopic liver transplantation: a pooled analysis of accuracy, perioperative and long term cardiovascular prognosis. Int J Cardiovasc Imaging. 2013 Dec;29(8):1741-8. doi: 10.1007/s10554-013-0275-x. Epub 2013 Aug 23. Review. PubMed PMID: 23974907. 7: Nguyen J, Juneman E, Movahed MR. The value of β-blockers administration during recovery phase of dobutamine stress echocardiography: a review. Echocardiography. 2013 Jul;30(6):723-9. doi: 10.1111/echo.12201. Epub 2013 Apr 8. Review. PubMed PMID: 23560565. 8: Passos LC, Barbosa AC, Oliveira MG, Santos EG Jr. Is there evidence favoring the use of beta-blockers and dobutamine in acute heart failure? Arq Bras Cardiol. 2013 Feb;100(2):190-7. Review. English, Portuguese. PubMed PMID: 23503830. 9: Shah SP, Chaudhry GM. Intracranial hemorrhage as a complication of dobutamine stress echocardiography: case report and review of the literature. Echocardiography. 2012 May;29(5):E119-21. doi: 10.1111/j.1540-8175.2011.01623.x. Review. PubMed PMID: 22537238. 10: Tacon CL, McCaffrey J, Delaney A. Dobutamine for patients with severe heart failure: a systematic review and meta-analysis of randomised controlled trials. Intensive Care Med. 2012 Mar;38(3):359-67. doi: 10.1007/s00134-011-2435-6. Epub 2011 Dec 8. Review. PubMed PMID: 22160239. 11: Kato M, Hirayama A. [Combination therapy; dobutamine and milrinone]. Nihon Rinsho. 2011 Nov;69 Suppl 9:428-33. Review. Japanese. PubMed PMID: 22724242. 12: Szymanski C, Pierard L, Lancellotti P. Imaging techniques in coronary atherosclerotic disease: dobutamine stress echocardiography--evidence and perspectives. J Cardiovasc Med (Hagerstown). 2011 Aug;12(8):543-53. doi: 10.2459/JCM.0b013e32834853f8. Review. PubMed PMID: 21709580. 13: Charoenpanichkit C, Hundley WG. The 20 year evolution of dobutamine stress cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2010 Oct 26;12:59. doi: 10.1186/1532-429X-12-59. Review. PubMed PMID: 20977757; PubMed Central PMCID: PMC2984575. 14: Geleijnse ML, Krenning BJ, Nemes A, van Dalen BM, Soliman OI, Ten Cate FJ, Schinkel AF, Boersma E, Simoons ML. Incidence, pathophysiology, and treatment of complications during dobutamine-atropine stress echocardiography. Circulation. 2010 Apr 20;121(15):1756-67. doi: 10.1161/CIRCULATIONAHA.109.859264. Review. PubMed PMID: 20404267. 15: Hakeem A, Cilingiroglu M, Leesar MA. Hemodynamic and intravascular ultrasound assessment of myocardial bridging: fractional flow reserve paradox with dobutamine versus adenosine. Catheter Cardiovasc Interv. 2010 Feb 1;75(2):229-36. doi: 10.1002/ccd.22237. Review. PubMed PMID: 19753633. 16: Geleijnse ML, Krenning BJ, van Dalen BM, Nemes A, Soliman OI, Bosch JG, Galema TW, ten Cate FJ, Boersma E. Factors affecting sensitivity and specificity of diagnostic testing: dobutamine stress echocardiography. J Am Soc Echocardiogr. 2009 Nov;22(11):1199-208. doi: 10.1016/j.echo.2009.07.006. Epub 2009 Sep 18. Review. PubMed PMID: 19766453. 17: Klaas JP, Diller CL, Harmon JV, Skarda DE. Death caused by splenic artery aneurysm rupture during dobutamine-atropine stress echocardiography: case report and literature review. Echocardiography. 2009 Jan;26(1):93-5. doi: 10.1111/j.1540-8175.2008.00755.x. Review. PubMed PMID: 19125812. 18: Tas H, Gundogdu F, Gurlertop Y, Karakelleoglu S. Dobutamine stress echocardiography and tissue synchronization imaging. Eurasian J Med. 2008 Aug;40(2):83-4. Review. PubMed PMID: 25610034; PubMed Central PMCID: PMC4261678. 19: Bangalore S, Hematpour K, Chaudhry FA. Dobutamine stress echocardiography: does it predict response to beta-blockers in patients with heart failure? Curr Heart Fail Rep. 2006 Jun;3(2):96-102. Review. PubMed PMID: 16933402. 20: Strach K, Meyer C, Schild H, Sommer T. Cardiac stress MR imaging with dobutamine. Eur Radiol. 2006 Dec;16(12):2728-38. Epub 2006 May 20. Review. PubMed PMID: 16715237.