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MedKoo Cat#: 465690 | Name: AVT-18A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AVT-18A is NOSH-releasing NSAID analog.

Chemical Structure

AVT-18A
AVT-18A
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465690

Name: AVT-18A

CAS#: unknown

Chemical Formula: C40H30FNO10S4

Exact Mass: 831.0737

Molecular Weight: 831.92

Elemental Analysis: C, 57.75; H, 3.63; F, 2.28; N, 1.68; O, 19.23; S, 15.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AVT-18A; AVT18A; AVT 18A;
IUPAC/Chemical Name
4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl (Z)-5-(2-(5-fluoro-2-methyl-1-(4-(methylsulfinyl)benzylidene)-1H-inden-3-yl)acetoxy)-2-((4-(nitrooxy)butanoyl)oxy)benzoate
InChi Key
OZUZUFKEWHZPJR-MNBJERMJSA-N
InChi Code
InChI=1S/C40H30FNO10S4/c1-23-31(18-24-5-13-29(14-6-24)56(2)48)30-15-9-26(41)19-33(30)32(23)21-38(44)50-28-12-16-35(52-37(43)4-3-17-49-42(46)47)34(20-28)40(45)51-27-10-7-25(8-11-27)36-22-39(53)55-54-36/h5-16,18-20,22H,3-4,17,21H2,1-2H3/b31-18-
SMILES Code
O=C(CCCO[N+]([O-])=O)OC1=CC=C(OC(CC2=C(C)/C(C3=CC=C(F)C=C32)=C/C4=CC=C(S(C)=O)C=C4)=O)C=C1C(OC5=CC=C(C6=CC(SS6)=S)C=C5)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 831.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kashfi K, Chattopadhyay M, Kodela R. NOSH-sulindac (AVT-18A) is a novel nitric oxide- and hydrogen sulfide-releasing hybrid that is gastrointestinal safe and has potent anti-inflammatory, analgesic, antipyretic, anti-platelet, and anti-cancer properties. Redox Biol. 2015 Dec;6:287-296. doi: 10.1016/j.redox.2015.08.012. Epub 2015 Aug 14. PMID: 26298203; PMCID: PMC4556776. 2: Kodela R, Chattopadhyay M, Kashfi K. Synthesis and biological activity of NOSH-naproxen (AVT-219) and NOSH-sulindac (AVT-18A) as potent anti-inflammatory agents with chemotherapeutic potential. Medchemcomm. 2013;4(11):10.1039/C3MD00185G. doi: 10.1039/C3MD00185G. PMID: 24273639; PMCID: PMC3835719.