MedKoo Cat#: 464577 | Name: 4557W
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

4557W is an Epidermal growth factor receptor (EGFR) inhibitor.

Chemical Structure

4557W
4557W
CAS#179248-61-4

Theoretical Analysis

MedKoo Cat#: 464577

Name: 4557W

CAS#: 179248-61-4

Chemical Formula: C23H21N3O3

Exact Mass: 387.1583

Molecular Weight: 387.44

Elemental Analysis: C, 71.30; H, 5.46; N, 10.85; O, 12.39

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
5mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
4557W; 4557 W; 4557-W; EGFR/ErbB-2 Inhibitor; EGFR/ErbB 2 Inhibitor;
IUPAC/Chemical Name
N-(4-(benzyloxy)phenyl)-6,7-dimethoxyquinazolin-4-amine
InChi Key
DNOKYISWMVFYFA-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H21N3O3/c1-27-21-12-19-20(13-22(21)28-2)24-15-25-23(19)26-17-8-10-18(11-9-17)29-14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,24,25,26)
SMILES Code
COC1=CC2=NC=NC(NC3=CC=C(OCC4=CC=CC=C4)C=C3)=C2C=C1OC
Appearance
Solid powder
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 387.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Godek J, Sargiannidou I, Patel S, Hurd L, Rothman VL, Tuszynski GP. Angiocidin inhibits breast cancer proliferation through activation of epidermal growth factor receptor and nuclear factor kappa (NF-ĸB). Exp Mol Pathol. 2011 Jun;90(3):244-51. doi: 10.1016/j.yexmp.2011.01.002. Epub 2011 Jan 15. PMID: 21241690; PMCID: PMC3092007.