TBK1 PROTAC® 3i is a Potent TANK-binding kinase 1 (TBK1) Degrader. It exhibits >50-fold selectivity for TBK1 over the closely related IKKε. It comprises a ligand for von-Hippel Lindau (VHL) protein joined by a linker to a TBK1-targeting moiety. It brings about near complete degradation of TBK1 in mutant K-Ras and wild-type cancer cell lines with no significant effect of proliferation.
MedKoo Cat#: 463297
Name: TBK1 PROTAC 3i
CAS#: 2052306-13-3
Chemical Formula: C53H74BrN9O9S
Exact Mass: 1091.4514
Molecular Weight: 1093.19
Elemental Analysis: C, 58.23; H, 6.82; Br, 7.31; N, 11.53; O, 13.17; S, 2.93
The following data is based on the product molecular weight 1,093.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
