Hoe 892 | CAS#75111-35-2 | antiplatlet

MedKoo Cat#: 461654 | Name: Hoe 892

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Hoe 892 is a stable thia-thimo-analogue of prostacyclin and acts as a platelet aggregation inhibitor.

Chemical Structure

Hoe 892

CAS#75111-35-2

Theoretical Analysis

MedKoo Cat#: 461654

Name: Hoe 892

CAS#: 75111-35-2

Chemical Formula: C20H33NO4S

Exact Mass: 383.2130

Molecular Weight: 383.54

Elemental Analysis: C, 62.63; H, 8.67; N, 3.65; O, 16.69; S, 8.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Hoe 892; Hoe-892; Hoe892; S 792892A; S-792892A; S792892A;

IUPAC/Chemical Name

methyl 4-(((3aR,4R,5R,6aS)-5-hydroxy-4-((S,E)-3-hydroxyoct-1-en-1-yl)-3,3a,4,5,6,6a-hexahydrocyclopenta[b]pyrrol-2-yl)thio)butanoate

InChi Key

TUOQTRVLPKMMDB-KNAQOGQBSA-N

InChi Code

InChI=1S/C20H33NO4S/c1-3-4-5-7-14(22)9-10-15-16-12-19(21-17(16)13-18(15)23)26-11-6-8-20(24)25-2/h9-10,14-18,22-23H,3-8,11-13H2,1-2H3/b10-9+/t14-,15+,16+,17-,18+/m0/s1

SMILES Code

O=C(OC)CCCSC1=N[C@]2([H])[C@]([C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C2)([H])C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 383.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Konturek SJ, Brzozowski T, Radecki T, Pastucki I. Comparison of gastric and intestinal antisecretory and protective effects of prostacyclin and its stable thia-imino-analogue (Hoe 892) in conscious rats. Prostaglandins. 1984 Oct;28(4):443-53. PubMed PMID: 6395196. 2: Schölkens BA, Gehring D, Jung W. The orally active thia-imino-prostacyclin Hoe 892: antiaggregatory and cardiovascular activities. Prostaglandins Leukot Med. 1983 Mar;10(3):231-56. PubMed PMID: 6405394.