Synonym
HWL-088; HWL088; HWL 088;
IUPAC/Chemical Name
2-(2-fluoro-4-((2'-methyl-[1,1'-biphenyl]-3-yl)methoxy)phenoxy)acetic acid
InChi Key
NJYJBYPNDWNZAH-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H19FO4/c1-15-5-2-3-8-19(15)17-7-4-6-16(11-17)13-26-18-9-10-21(20(23)12-18)27-14-22(24)25/h2-12H,13-14H2,1H3,(H,24,25)
SMILES Code
CC1=CC=CC=C1C2=CC(COC3=CC=C(OCC(O)=O)C(F)=C3)=CC=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
366.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hu L, Zhou Z, Deng L, Ren Q, Cai Z, Wang B, Li Z, Wang G. HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis. J Pharm Pharmacol. 2020 Nov;72(11):1564-1573. doi: 10.1111/jphp.13342. Epub 2020 Jul 31. PMID: 32734608.
2: Chen Y, Ren Q, Zhou Z, Deng L, Hu L, Zhang L, Li Z. HWL-088, a new potent free fatty acid receptor 1 (FFAR1) agonist, improves glucolipid metabolism and acts additively with metformin in ob/ob diabetic mice. Br J Pharmacol. 2020 May;177(10):2286-2302. doi: 10.1111/bph.14980. Epub 2020 Feb 8. PMID: 31971610; PMCID: PMC7174891.
3: Li Z, Ren Q, Wang X, Zhou Z, Hu L, Deng L, Guan L, Qiu Q. Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold. Bioorg Chem. 2019 Nov;92:103209. doi: 10.1016/j.bioorg.2019.103209. Epub 2019 Aug 16. PMID: 31487621.
