Kolavenol | CAS#19941-83-4 | rootbark extract

MedKoo Cat#: 558561 | Name: Kolavenol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Kolavenol is a drug from rootbark extract of Entada abyssinica.

Chemical Structure

Kolavenol

CAS#19941-83-4

Theoretical Analysis

MedKoo Cat#: 558561

Name: Kolavenol

CAS#: 19941-83-4

Chemical Formula: C20H34O

Exact Mass: 290.2600

Molecular Weight: 290.49

Elemental Analysis: C, 82.69; H, 11.80; O, 5.51

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Kolavenol; (-)-Kolavenol;

IUPAC/Chemical Name

(E)-3-methyl-5-((1S,2R,4aS,8aR)-1,2,4a,5-tetramethyl-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl)pent-2-en-1-ol

InChi Key

PQTMZYKTDFKGKV-DGLGTODWSA-N

InChi Code

InChI=1S/C20H34O/c1-15(11-14-21)9-12-19(4)17(3)10-13-20(5)16(2)7-6-8-18(19)20/h7,11,17-18,21H,6,8-10,12-14H2,1-5H3/b15-11+/t17-,18-,19+,20-/m1/s1

SMILES Code

CC1=CCC[C@@H]2[C@@]([C@H](C)CC[C@]12C)(C)CC/C(C)=C/CO

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 290.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Freiburghaus F, Steck A, Pfander H, Brun R. Bioassay-guided isolation of a diastereoisomer of kolavenol from Entada abyssinica active on Trypanosoma brucei rhodesiense. J Ethnopharmacol. 1998 Jul;61(3):179-83. PubMed PMID: 9705008. 2: Liu Y, Wiedle CH Jr, Brodie PJ, Callmander MW, Rakotondrajaona R, Rakotobe E, Rasamison VE, Kingston DG. Antiproliferative Diterpenes from a Malleastrum sp. from the Madagascar dry forest. Nat Prod Commun. 2015 Sep;10(9):1509-12. PubMed PMID: 26594745; PubMed Central PMCID: PMC4689295. 3: Kawakami S, Harinantenaina L, Matsunami K, Otsuka H, Shinzato T, Takeda Y. Macaflavanones A-G, prenylated flavanones from the leaves of Macaranga tanarius. J Nat Prod. 2008 Nov;71(11):1872-6. doi: 10.1021/np800380d. Epub 2008 Oct 10. PubMed PMID: 18844422. 4: Tang W, Harada K, Kubo M, Hioki H, Fukuyama Y. Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides. Nat Prod Commun. 2011 Mar;6(3):327-32. PubMed PMID: 21485268. 5: Lu T, Vargas D, Franzblau SG, Fischer NH. Diterpenes from Solidago rugosa. Phytochemistry. 1995 Jan;38(2):451-6. PubMed PMID: 7772306. 6: Chen X, Berim A, Dayan FE, Gang DR. A (-)-kolavenyl diphosphate synthase catalyzes the first step of salvinorin A biosynthesis in Salvia divinorum. J Exp Bot. 2017 Feb 1;68(5):1109-1122. doi: 10.1093/jxb/erw493. PubMed PMID: 28204567; PubMed Central PMCID: PMC5441855.