Norspermidine | CAS# 56-18-8 | cancer medication

MedKoo Cat#: 413818 | Name: Norspermidine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Norspermidine is a polyamine of similar structure to the more common spermidine. While norspermidine has been found to occur naturally in some species of plants, bacteria, and algae, it is not known to exist in humans. Norspermidine is being researched for use as a cancer medication.

Chemical Structure

Norspermidine

CAS#56-18-8

Theoretical Analysis

MedKoo Cat#: 413818

Name: Norspermidine

CAS#: 56-18-8

Chemical Formula: C6H17N3

Exact Mass: 131.1422

Molecular Weight: 131.22

Elemental Analysis: C, 54.92; H, 13.06; N, 32.02

Price and Availability

Size	Price	Availability	Quantity
100g	USD 280.00	2 Weeks
500g	USD 413.00	2 Weeks

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Related CAS #

No Data

Synonym

Norspermidine; NSC7773; NSC-7773; NSC 7773

IUPAC/Chemical Name

N1-(3-aminopropyl)propane-1,3-diamine

InChi Key

OTBHHUPVCYLGQO-UHFFFAOYSA-N

InChi Code

InChI=1S/C6H17N3/c7-3-1-5-9-6-2-4-8/h9H,1-8H2

SMILES Code

NCCCNCCCN

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Norspermidine is a polyamine of similar structure to the more common spermidine.

In vitro activity:

This work aimed to study the effect of Nspd (norspermidine) on mature Candida albicans biofilms and to investigate how Nspd would influence human dental pulp stem cells (DPSCs). These biofilm assays indicated that 111.7 and 55.9 mM Nspd dispersed 48 h mature fungal biofilms and showed significant fungicidal effect. 27.9 and 14.0 mM Nspd showed moderate fungicidal effect. 111.7-14.0 mM Nspd showed a dose- inhibitory effect on mature fungal biofilm, where 14.0 mM Nspd reduced the metabolic activity by half compared with blank control. Reference: Front Bioeng Biotechnol. 2020 Aug 12;8:948. https://pubmed.ncbi.nlm.nih.gov/32903416/

In vivo activity:

TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 131.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

1. He Y, Cao Y, Xiang Y, Hu F, Tang F, Zhang Y, Albashari AA, Xing Z, Luo L, Sun Y, Huang Q, Ye Q, Zhang K. An Evaluation of Norspermidine on Anti-fungal Effect on Mature Candida albicans Biofilms and Angiogenesis Potential of Dental Pulp Stem Cells. Front Bioeng Biotechnol. 2020 Aug 12;8:948. doi: 10.3389/fbioe.2020.00948. PMID: 32903416; PMCID: PMC7434867. 2. Nishio T, Yoshikawa Y, Shew CY, Umezawa N, Higuchi T, Yoshikawa K. Specific effects of antitumor active norspermidine on the structure and function of DNA. Sci Rep. 2019 Oct 18;9(1):14971. doi: 10.1038/s41598-019-50943-1. PMID: 31628357; PMCID: PMC6802174.

In vitro protocol:

In vivo protocol:

TBD

1: Wotanis CK, Brennan WP 3rd, Angotti AD, Villa EA, Zayner JP, Mozina AN, Rutkovsky AC, Sobe RC, Bond WG, Karatan E. Relative contributions of norspermidine synthesis and signaling pathways to the regulation of Vibrio cholerae biofilm formation. PLoS One. 2017 Oct 18;12(10):e0186291. doi: 10.1371/journal.pone.0186291. PMID: 29045455; PMCID: PMC5646818. 2: Hobley L, Kim SH, Maezato Y, Wyllie S, Fairlamb AH, Stanley-Wall NR, Michael AJ. Norspermidine is not a self-produced trigger for biofilm disassembly. Cell. 2014 Feb 13;156(4):844-54. doi: 10.1016/j.cell.2014.01.012. PMID: 24529384; PMCID: PMC3969229. 3: Ou M, Ling J. Norspermidine changes the basic structure of S. mutans biofilm. Mol Med Rep. 2017 Jan;15(1):210-220. doi: 10.3892/mmr.2016.5979. Epub 2016 Dec 5. PMID: 27922663; PMCID: PMC5355703. 4: Sun Y, Pan Y, Sun Y, Li M, Huang S, Qiu W, Tu H, Zhang K. Effects of Norspermidine on Dual-Species Biofilms Composed of Streptococcus mutans and Streptococcus sanguinis. Biomed Res Int. 2019 Nov 3;2019:1950790. doi: 10.1155/2019/1950790. PMID: 31781595; PMCID: PMC6874952. 5: Qu L, She P, Wang Y, Liu F, Zhang D, Chen L, Luo Z, Xu H, Qi Y, Wu Y. Effects of norspermidine on Pseudomonas aeruginosa biofilm formation and eradication. Microbiologyopen. 2016 Jun;5(3):402-12. doi: 10.1002/mbo3.338. Epub 2016 Jan 27. PMID: 26817804; PMCID: PMC4905993. 6: Cardile AP, Woodbury RL, Sanchez CJ Jr, Becerra SC, Garcia RA, Mende K, Wenke JC, Akers KS. Activity of Norspermidine on Bacterial Biofilms of Multidrug- Resistant Clinical Isolates Associated with Persistent Extremity Wound Infections. Adv Exp Med Biol. 2017;973:53-70. doi: 10.1007/5584_2016_93. PMID: 27864804; PMCID: PMC5438303. 7: Nishio T, Yoshikawa Y, Shew CY, Umezawa N, Higuchi T, Yoshikawa K. Specific effects of antitumor active norspermidine on the structure and function of DNA. Sci Rep. 2019 Oct 18;9(1):14971. doi: 10.1038/s41598-019-50943-1. PMID: 31628357; PMCID: PMC6802174. 8: Bolard A, Schniederjans M, Haüssler S, Triponney P, Valot B, Plésiat P, Jeannot K. Production of Norspermidine Contributes to Aminoglycoside Resistance in pmrAB Mutants of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2019 Sep 23;63(10):e01044-19. doi: 10.1128/AAC.01044-19. PMID: 31383668; PMCID: PMC6761568. 9: Ramón-Peréz ML, Díaz-Cedillo F, Contreras-Rodríguez A, Betanzos-Cabrera G, Peralta H, Rodríguez-Martínez S, Cancino-Diaz ME, Jan-Roblero J, Cancino Diaz JC. Different sensitivity levels to norspermidine on biofilm formation in clinical and commensal Staphylococcus epidermidis strains. Microb Pathog. 2015 Feb;79:8-16. doi: 10.1016/j.micpath.2014.12.004. Epub 2014 Dec 27. PMID: 25549879. 10: Si X, Quan X, Wu Y. A small-molecule norspermidine and norspermidine-hosting polyelectrolyte coatings inhibit biofilm formation by multi-species wastewater culture. Appl Microbiol Biotechnol. 2015 Dec;99(24):10861-70. doi: 10.1007/s00253-015-6943-0. Epub 2015 Sep 9. PMID: 26350146.