Nortopixantrone hydrochloride | CAS#438244-41-8 | 156090-17-4 | topoisomerase inhibitor

MedKoo Cat#: 329448 | Name: Nortopixantrone HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Nortopixantrone, also known as BBR-3438, is a DNA topoisomerase inhibitor potentially for thetreatment of gastric cancer, ovarian cancer. BR 3438 exhibited a unique profile of preclinical activity with a superior efficacy against prostatic carcinoma models compared to reference compounds (doxorubicin and losoxantrone). The antitumour efficacy of BBR 3438 against prostatic carcinoma could be the result of a combination of favourable events, including enhanced intracellular accumulation and an increased DNA-binding affinity favouring the accumulation of multiple sublethal or lethal damage.

Chemical Structure

Nortopixantrone HCl

CAS#438244-41-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 329448

Name: Nortopixantrone HCl

CAS#: 438244-41-8 (HCl)

Chemical Formula: C20H26Cl2N6O2

Exact Mass: 452.1494

Molecular Weight: 453.37

Elemental Analysis: C, 52.99; H, 5.78; Cl, 15.64; N, 18.54; O, 7.06

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

156090-17-4 (free base); 438244-41-8 (HCl)

Synonym

Nortopixantrone hydrochloride; BBR-3438; BBR3438; BBR3438.

IUPAC/Chemical Name

2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino)indazolo[4,3-gh]isoquinolin-6(2H)-one dihydrochloride

InChi Key

PBBLZEYTDDWEIH-UHFFFAOYSA-N

InChi Code

InChI=1S/C20H24N6O2.2ClH/c1-21-6-7-24-15-2-3-16-18-17(15)20(28)13-4-5-23-12-14(13)19(18)25-26(16)10-8-22-9-11-27;;/h2-5,12,21-22,24,27H,6-11H2,1H3;2*1H

SMILES Code

O=C1C2=C(C=NC=C2)C3=NN(CCNCCO)C4=C3C1=C(NCCNC)C=C4.[H]Cl.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Related CAS# 156090-17-4 (Nortopixantrone free base) 438244-41-8 (Nortopixantrone hydrochloride)

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 453.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hofheinz RD, Porta C, Hartung G, Santoro A, Hanauske AR, Kutz K, Stern A, Barbieri P, Verdi E, Hehlmann R, Hochhaus A. BBR 3438, a novel 9-aza-anthrapyrazole, in patients with advanced gastric cancer: a phase II study group trial of the Central European Society of Anticancer-Drug Research (CESAR). Invest New Drugs. 2005 Aug;23(4):363-8. PubMed PMID: 16012796. 2: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jan-Feb;25(1):53-76. PubMed PMID: 12690708. 3: Supino R, Polizzi D, Pavesi R, Pratesi G, Guano F, Capranico G, Palumbo M, Sissi C, Richter S, Beggiolin G, Menta E, Pezzoni G, Spinelli S, Torriani D, Carenini N, Dal Bo L, Facchinetti F, Tortoreto M, Zunino F. A novel 9-aza-anthrapyrazole effective against human prostatic carcinoma xenografts. Oncology. 2001;61(3):234-42. PubMed PMID: 11574780.