CAY10773 is a derivative of the ferroptosis inducer sorafenib. It selectively inhibits proliferation of BEL-7402, MGC803, and T24 bladder cancer cells over non-cancerous HCV-29 cells. CAY10773 induces apoptosis in T24 cells when used at concentrations ranging from 2 to 6 µM but induces ferroptosis at concentrations greater than or equal to 6 µM with 10 hour or longer incubation times. It increases the production of reactive oxygen species (ROS) and decreases the mitochondrial membrane potential in T24 cells. CAY10773 also induces autophagy with incubation times longer than eight hours.
MedKoo Cat#: 463461
Name: CAY10773
CAS#: 1648546-79-5
Chemical Formula: C22H17Cl2N5O
Exact Mass: 437.0810
Molecular Weight: 438.31
Elemental Analysis: C, 60.29; H, 3.91; Cl, 16.18; N, 15.98; O, 3.65
The following data is based on the product molecular weight 438.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
