Synonym
Diphemanil Free Base; Diphemanil cation; Diphemanil ion
IUPAC/Chemical Name
4-(Diphenylmethylene)-1,1-dimethylpiperidinium
InChi Key
InChI=1S/C20H24N/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12H,13-16H2,1-2H3/q+1
InChi Code
InChI=1S/C20H24N/c1-21(2)15-13-19(14-16-21)20(17-9-5-3-6-10-17)18-11-7-4-8-12-18/h3-12H,13-16H2,1-2H3/q+1
SMILES Code
C[N+]1(C)CC/C(CC1)=C(C2=CC=CC=C2)\C3=CC=CC=C3
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
278.42
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: HACKBARTH DE, MARKSON LS. Diphemanil methylsulfate hyperhidrosis. Arch Dermatol. 1961 Apr;83:659. doi: 10.1001/archderm.1961.01580100123018. PMID: 13710268.
2: Vidal AM, Rey E, Pons G, Pello JY, d'Athis P, Olive G. Pharmacokinetics of diphemanil methylsulphate in healthy subjects. Eur J Clin Pharmacol. 1992;42(6):689-91. doi: 10.1007/BF00265939. PMID: 1623915.
3: Chéron G, Vidal AM, Rey E, Pons G, d'Athis P, Olive G. Pharmacocinétique du diphémanil méthylsulfate chez le nourrisson [Pharmacokinetics of diphemanil methylsulfate in infants]. Arch Pediatr. 1994 Jan;1(1):33-7. French. PMID: 8087216.
4: Laccourreye O, Bonan B, Brasnu D, Laccourreye H. Treatment of Frey's syndrome with topical 2% diphemanil methylsulfate (Prantal): a double-blind evaluation of 15 patients. Laryngoscope. 1990 Jun;100(6):651-3. doi: 10.1288/00005537-199006000-00019. PMID: 2190054.
5: Diamond L, O'Donnell M. A comparative study of two parasympatholytic bronchodilator agents: ipratropium bromide and diphemanil methylsulfate. J Pharmacol Exp Ther. 1981 Jan;216(1):1-5. PMID: 6450282.
6: Bennasr S, Baumann C, Casadevall I, Bompard Y, Jacqz-Aigrain E. Bloc auriculo-ventriculaire compliquant l'utilisation du diphémanil (Prantal) chez deux nouveau-nés prématurés [Atrioventricular block complicating the use of diphemanil (Prantal) in 2 premature newborn infants]. Arch Fr Pediatr. 1993 May;50(5):413-5. French. PMID: 8239894.
7: Vidal AM, Chéron G, Rey E, Pons G, d'Athis P, Olive G. Pharmacokinetics of diphemanil methylsulphate in infants. Eur J Clin Pharmacol. 1993;45(1):89-91. doi: 10.1007/BF00315356. PMID: 8405036.
8: Biran-Mucignat V, Flamant C, Lachtar M, Perrot C, Chauty A, Novakova J, Lavallée I, Mitanchez D, Aujard Y, Gold F. Enquête française sur l'utilisation du diphémanil méthylsulfate (Prantal) dans les unités de néonatologie [Determinants of diphemanil methylsulfate (Prantal) utilization: a survey of practice in the French neonatal and intensive care units]. Arch Pediatr. 2007 Mar;14(3):254-8. French. doi: 10.1016/j.arcped.2006.11.017. Epub 2006 Dec 18. PMID: 17175143.
9: FISHER C. Preliminary report on the use of diphemanil methylsulfate (Prantal) 2 per cent dusting powder in hyperhidrosis and bromhidrosis. J Am Podiatry Assoc. 1963 Aug;53:595-6. PMID: 13945267.
10: Do B, Goulay-Dufaÿ S, Le Hoang MD, Adoui N, Graffard H, Guyon F, Pradeau D. Sensitive quantification of diphemanil methyl sulphate in human plasma by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jan 1;845(1):104-8. doi: 10.1016/j.jchromb.2006.07.057. Epub 2006 Sep 7. PMID: 16962397.
