CGP53353 is a selective inhibitor of PKCβII (IC50 values are 0.41 and 3.8 μM for PKCβII and PKCβI respectively). CGP53353 also inhibits prionogenic Sup35 fibrillization (IC50 ~ 3.4 μM) and inhibits de novo Aβ42 assembly in vitro.
MedKoo Cat#: 513675
Name: CGP53353
CAS#: 145915-60-2
Chemical Formula: C20H13F2N3O2
Exact Mass: 365.0976
Molecular Weight: 365.34
Elemental Analysis: C, 65.75; H, 3.59; F, 10.40; N, 11.50; O, 8.76
The following data is based on the product molecular weight 365.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
