CN-SAH is a potent and selective inhibitor of DOT1L activity. The polar 5-nitrile group of CN-SAH was shown by crystallography to bind in the hydrophobic pocket of DOT1L. In addition, that polar nitrile group can be used as a non-traditional replacement for heavy halogen atoms.
MedKoo Cat#: 561255
Name: CN-SAH
CAS#: 1985669-27-9
Chemical Formula: C16H20N6O5S
Exact Mass: 408.1216
Molecular Weight: 408.43
Elemental Analysis: C, 47.05; H, 4.94; N, 20.58; O, 19.59; S, 7.85
The following data is based on the product molecular weight 408.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
