Dimoxyline HCl | CAS# 5807-56-7 (HCl) | angina pectoris

MedKoo Cat#: 413770 | Name: Dimoxyline HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimoxyline HCl is the salt form of Dimoxyline, the synthetic analogue of papaverine, Acute toxicity studies show it to be less toxic than papaverine. No analgesic action and no tolerance development in experimental animals by repeated administration. But Dimoxyline does not appear to be as potent as papaverine in comparable dosage. Dimoxyline is indicated for the treatment of patients with angina pectoris. Also, significant amount of benefit was claimed in patients with acute or chronic phlebitis, arterial thrombosis or embolism, Raynaud’s phenomena and early thromboangiitis obliterans or arteriosclerosis obliterans. Detected adverse events are: nausea or abdominal cramps.

Chemical Structure

Dimoxyline HCl

CAS#5807-56-7 (HCl)

Theoretical Analysis

MedKoo Cat#: 413770

Name: Dimoxyline HCl

CAS#: 5807-56-7 (HCl)

Chemical Formula: C22H26ClNO4

Exact Mass:

Molecular Weight: 403.90

Elemental Analysis: C, 65.42; H, 6.49; Cl, 8.78; N, 3.47; O, 15.84

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

5807-56-7 (HCl) 147-27-3 (free base)

Synonym

Dimoxyline HCl; Dioxyline hydrochloride

IUPAC/Chemical Name

Isoquinoline, 1-(4-ethoxy-3-methoxybenzyl)-6,7-dimethoxy-3-methyl-, hydrochloride

InChi Key

MJBCABRMQNZIRC-UHFFFAOYSA-N

InChi Code

InChI=1S/C22H25NO4.ClH/c1-6-27-19-8-7-15(11-20(19)24-3)10-18-17-13-22(26-5)21(25-4)12-16(17)9-14(2)23-18;/h7-9,11-13H,6,10H2,1-5H3;1H

SMILES Code

CC1=CC2=C(C(CC3=CC=C(OCC)C(OC)=C3)=N1)C=C(OC)C(OC)=C2.[H]Cl

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 403.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Glennon RA. MDMA-like stimulus effects of alpha-ethyltryptamine and the alpha-ethyl homolog of DOM. Pharmacol Biochem Behav. 1993 Oct;46(2):459-62. doi: 10.1016/0091-3057(93)90379-8. PMID: 7903460. 2: Buyniski JP, Smith ML, Bierwagen ME. Cardiovascular and gross behavioral effects of amphetamine, 2-amino-1-(2,5-dimethoxy-4-methylphenyl) propane (DOM) and 2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A) in the conscious dog. Res Commun Chem Pathol Pharmacol. 1974 Jun;8(2):213-21. PMID: 4859236. 3: Tilson HA, Chamberlain JH, Gylys JA. Further studies on BL-3912A: effects on avoidance behavior of rats with low baselines and on reaction thresholds to electric footshock. Pharmacol Biochem Behav. 1977 Jun;6(6):627-30. doi: 10.1016/0091-3057(77)90086-7. PMID: 263545. 4: Standridge RT, Howell HG, Gylys JA, Partyka RA, Shulgin AT. Phenylakylamines with potential psychotherapeutic utility. 1. 2-Amino-1-(2,5-dimethoxy-4-methylphenyl)butane. J Med Chem. 1976 Dec;19(12):1400-4. doi: 10.1021/jm00234a010. PMID: 1003425. 5: Coppola RJ. An evaluation of 1-(4-methyl) 2, 5-dimethoxyphenyl-2-aminobutane (MDPA-1) as an enhancer of memory and learning. J Am Osteopath Assoc. 1974 Jan;73(5):406-11. PMID: 4209256. 6: Winter JC. Effects of the phenethylamine derivatives, BL-3912, fenfluramine, and Sch-12679, in rats trained with LSD as a discriminative stimulus. Psychopharmacology (Berl). 1980;68(2):159-62. doi: 10.1007/BF00432134. PMID: 6776559. 7: Dyer DC. Comparison of the effects of R-(-)-2-amino-1-(2,5-dimethoxy-4-methylphenyl) propane (DOM), r-(-)-2-amino-1-(2,5-dimethoxy-4-methylphenyl) butane (BL-3912A) and 5-hydroxytryptamine on non-innervated vascular smooth muscle. Res Commun Chem Pathol Pharmacol. 1976 Jul;14(3):449-54. PMID: 959651.