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MedKoo Cat#: 527895 | Name: Dimoxyline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimoxyline is the synthetic analogue of papaverine. Dimoxyline is indicated for the treatment of patients with angina pectoris. Also, significant amount of benefit was claimed in patients with acute or chronic phlebitis, arterial thrombosis or embolism, Raynaud’s phenomena and early thromboangiitis obliterans or arteriosclerosis obliterans. Detected adverse events are: nausea or abdominal cramps.

Chemical Structure

Dimoxyline
Dimoxyline
CAS#147-27-3 (free base)

Theoretical Analysis

MedKoo Cat#: 527895

Name: Dimoxyline

CAS#: 147-27-3 (free base)

Chemical Formula: C22H25NO4

Exact Mass: 367.1784

Molecular Weight: 367.45

Elemental Analysis: C, 71.91; H, 6.86; N, 3.81; O, 17.42

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
5807-56-7 (HCl) 147-27-3 (free base)
Synonym
Dimoxyline
IUPAC/Chemical Name
1-(4-Ethoxy-3-methoxybenzyl)-6,7-dimethoxy-3-methylisoquinoline
InChi Key
NFABMCCMPXXBFY-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H25NO4/c1-6-27-19-8-7-15(11-20(19)24-3)10-18-17-13-22(26-5)21(25-4)12-16(17)9-14(2)23-18/h7-9,11-13H,6,10H2,1-5H3
SMILES Code
CC1=CC2=C(C(CC3=CC=C(OCC)C(OC)=C3)=N1)C=C(OC)C(OC)=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Acute toxicity studies show it to be less toxic than papaverine. No analgesic action and no tolerance development in experimental animals by repeated administration. But Dimoxyline does not appear to be as potent as papaverine in comparable dosage.

Preparing Stock Solutions

The following data is based on the product molecular weight 367.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: HANNA C, PARKER RC. Papaverine analogs. 8. Comparative actions of papaverine, ethaverine and dioxyline on the cardiovascular system. Arch Int Pharmacodyn Ther. 1960 Jul 1;126:386-92. PubMed PMID: 14399525. 2: RUSSEK HI, ZOHMAN BL, DRUMM AE, WEINGARTEN W, DORSET VJ. Long-acting coronary vasodilator drugs: metamine, paveril, nitroglyn and peritrate. Circulation. 1955 Aug;12(2):169-75. PubMed PMID: 13240796. 3: DETERLING RA Jr. The use of dioxyline phosphate in peripheral vascular disorders. Angiology. 1953 Oct;4(5):397-405. PubMed PMID: 13092557. 4: COMER JP, KENNEDY EE. A spectrophotometric determination of dioxyline in plasma. J Lab Clin Med. 1953 Sep;42(3):479-84. PubMed PMID: 13085041. 5: FRISCH RA, KAUFMAN KK, BEEZY R, GARRY MW. Evaluation of paveril in angina pectoris. Am J Med Sci. 1952 Sep;224(3):304-7. PubMed PMID: 14952507. 6: SCOTT RC, SEIWERT VJ, FOWLER NO Jr, McGUIRE J. Studies on the use of dioxyline phosphate in the treatment of angina pectoris. Circulation. 1952 Jul;6(1):125-30. PubMed PMID: 14936209. 7: MEYER JM, CORRELL HL, PETERS BJ, LINDERT MC. Anginal relief with paveril phosphate. Am Pract Dig Treat. 1952 May;3(5):379-83. PubMed PMID: 14933711. 8: BEST MM, COE WS. Effects of dioxyline phosphate and enteric-coated khellin on coronary artery insufficiency. Am J Med Sci. 1951 Jul;222(1):35-9. PubMed PMID: 14846805. 1: HANNA C, PARKER RC. Papaverine analogs. 8. Comparative actions of papaverine, ethaverine and dioxyline on the cardiovascular system. Arch Int Pharmacodyn Ther. 1960 Jul 1;126:386-92. PubMed PMID: 14399525. 2: RUSSEK HI, ZOHMAN BL, DRUMM AE, WEINGARTEN W, DORSET VJ. Long-acting coronary vasodilator drugs: metamine, paveril, nitroglyn and peritrate. Circulation. 1955 Aug;12(2):169-75. PubMed PMID: 13240796. 3: DETERLING RA Jr. The use of dioxyline phosphate in peripheral vascular disorders. Angiology. 1953 Oct;4(5):397-405. PubMed PMID: 13092557. 4: COMER JP, KENNEDY EE. A spectrophotometric determination of dioxyline in plasma. J Lab Clin Med. 1953 Sep;42(3):479-84. PubMed PMID: 13085041. 5: FRISCH RA, KAUFMAN KK, BEEZY R, GARRY MW. Evaluation of paveril in angina pectoris. Am J Med Sci. 1952 Sep;224(3):304-7. PubMed PMID: 14952507. 6: SCOTT RC, SEIWERT VJ, FOWLER NO Jr, McGUIRE J. Studies on the use of dioxyline phosphate in the treatment of angina pectoris. Circulation. 1952 Jul;6(1):125-30. PubMed PMID: 14936209. 7: MEYER JM, CORRELL HL, PETERS BJ, LINDERT MC. Anginal relief with paveril phosphate. Am Pract Dig Treat. 1952 May;3(5):379-83. PubMed PMID: 14933711. 8: BEST MM, COE WS. Effects of dioxyline phosphate and enteric-coated khellin on coronary artery insufficiency. Am J Med Sci. 1951 Jul;222(1):35-9. PubMed PMID: 14846805.

View History

Dimoxamine HCl

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