Synonym
MES-IMPY; MESIMPY; MES IMPY;
IUPAC/Chemical Name
N,N-dimethyl-4-(6-(methylthio)imidazo[1,2-a]pyridin-2-yl)aniline
InChi Key
WOYCDVDURLTMAW-UHFFFAOYSA-N
InChi Code
1S/C16H17N3S/c1-18(2)13-6-4-12(5-7-13)15-11-19-10-14(20-3)8-9-16(19)17-15/h4-11H,1-3H3
SMILES Code
CSC1=CN2C=C(N=C2C=C1)C3=CC=C(C=C3)N(C)C
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
283.39
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Leung K. [S-methyl-11C]N,N-Dimethyl-4- (6-(methylthio)imidazo[1,2-a]pyridine-2-yl)aniline. 2007 Oct 6 [updated 2007 Nov 19]. In: Molecular Imaging and Contrast Agent Database (MICAD) [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2004–2013. PMID: 20641606.
2: Seneca N, Cai L, Liow JS, Zoghbi SS, Gladding RL, Hong J, Pike VW, Innis RB. Brain and whole-body imaging in nonhuman primates with [11C]MeS-IMPY, a candidate radioligand for beta-amyloid plaques. Nucl Med Biol. 2007 Aug;34(6):681-9. doi: 10.1016/j.nucmedbio.2007.06.002. PMID: 17707808.
3: Cai L, Liow JS, Zoghbi SS, Cuevas J, Baetas C, Hong J, Shetty HU, Seneca NM, Brown AK, Gladding R, Temme SS, Herman MM, Innis RB, Pike VW. Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amyloid plaques in Alzheimer's disease. J Med Chem. 2008 Jan 10;51(1):148-58. doi: 10.1021/jm700970s. Epub 2007 Dec 14. PMID: 18078311.
