Ceftiofur | CAS# 80370-57-6 | Antibiotic

MedKoo Cat#: 574465 | Name: Ceftiofur

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ceftiofur is a third generation cephalosporin antibiotic for use against antibiotic resistance enzyme beta-lactamase.

Chemical Structure

Ceftiofur

CAS#80370-57-6 (free)

Theoretical Analysis

MedKoo Cat#: 574465

Name: Ceftiofur

CAS#: 80370-57-6 (free)

Chemical Formula: C19H17N5O7S3

Exact Mass: 523.0290

Molecular Weight: 523.55

Elemental Analysis: C, 43.59; H, 3.27; N, 13.38; O, 21.39; S, 18.37

Price and Availability

Size	Price	Availability
25mg	USD 250.00	2 Weeks
50mg	USD 450.00	2 Weeks
100mg	USD 750.00	2 Weeks

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Related CAS #

80370-57-6 (free) 103980-44-5 (HCl) 104010-37-9 (sodium)

Synonym

Ceftiofur; CM 31916; Excede

IUPAC/Chemical Name

(6R,7R)-7-[[(2Z)-(2-Amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid

InChi Key

ZBHXIWJRIFEVQY-IHMPYVIRSA-N

InChi Code

InChI=1S/C19H17N5O7S3/c1-30-23-11(9-7-34-19(20)21-9)14(25)22-12-15(26)24-13(17(27)28)8(5-32-16(12)24)6-33-18(29)10-3-2-4-31-10/h2-4,7,12,16H,5-6H2,1H3,(H2,20,21)(H,22,25)(H,27,28)/b23-11-/t12-,16-/m1/s1

SMILES Code

O=C(C(N12)=C(CSC(C3=CC=CO3)=O)CS[C@]2([H])[C@H](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 523.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Carson C, Li XZ, Agunos A, Loest D, Chapman B, Finley R, Mehrotra M, Sherk LM, Gaumond R, Irwin R. Ceftiofur-resistant Salmonella enterica serovar Heidelberg of poultry origin - a risk profile using the Codex framework. Epidemiol Infect. 2019 Nov 4;147:e296. doi: 10.1017/S0950268819001778. PMID: 31679543; PMCID: PMC6836576. 2: Reppert EJ. Evidence for the use of ceftiofur for treatment of metritis in dairy cattle. Vet Clin North Am Food Anim Pract. 2015 Mar;31(1):139-49, vii. doi: 10.1016/j.cvfa.2014.11.007. Epub 2015 Jan 9. PMID: 25578388. 3: Pradella GD, Taschetto PM, Duarte CA, da Silva Azevedo M, Góss GC. Ceftiofur Side Effect in a Mare-Case Report. J Equine Vet Sci. 2020 Dec;95:103295. doi: 10.1016/j.jevs.2020.103295. Epub 2020 Oct 12. PMID: 33276911. 4: Hornish RE, Kotarski SF. Cephalosporins in veterinary medicine - ceftiofur use in food animals. Curr Top Med Chem. 2002 Jul;2(7):717-31. doi: 10.2174/1568026023393679. PMID: 12052187. 5: Kausche FM, Robb EJ. A comprehensive review of ceftiofur sodium and hydrochloride formulations for treatment of acute bovine foot rot. Vet Ther. 2003 Spring;4(1):83-93. PMID: 12756639. 6: Fan S, Foster D, Miller WG, Osborne J, Kathariou S. Impact of Ceftiofur Administration in Steers on the Prevalence and Antimicrobial Resistance of Campylobacter spp. Microorganisms. 2021 Feb 4;9(2):318. doi: 10.3390/microorganisms9020318. PMID: 33557120; PMCID: PMC7913856. 7: Chu X, Song K, Xu K, Zhang X, Zhang X, Song Y, Wang D, Liu S, Deng X. Ceftiofur attenuates lipopolysaccharide-induced acute lung injury. Int Immunopharmacol. 2010 May;10(5):600-4. doi: 10.1016/j.intimp.2010.02.010. Epub 2010 Mar 1. PMID: 20193778. 8: Silva TV, de Oliveira EB, Pérez-Báez J, Risco CA, Chebel RC, Cunha F, Daetz R, Santos JEP, Lima FS, Jeong KC, Galvão KN. Economic comparison between ceftiofur-treated and nontreated dairy cows with metritis. J Dairy Sci. 2021 Aug;104(8):8918-8930. doi: 10.3168/jds.2020-19430. Epub 2021 Apr 30. PMID: 33934874. 9: Macpherson ML, Giguère S, Pozor MA, Runcan E, Vickroy TW, Benson SA, Troedsson MHT, Hatzel JN, Larson J, Vanden Berg E, Kelleman AA, Sanchez LC, LeBlanc MM. Pharmacokinetics of ceftiofur sodium in equine pregnancy. J Vet Pharmacol Ther. 2017 Dec;40(6):656-662. doi: 10.1111/jvp.12399. Epub 2017 Mar 19. PMID: 28317126. 10: Vilos C, Constandil L, Rodas PI, Cantin M, Zepeda K, Herrera N, Velasquez LA. Evaluation of ceftiofur-PHBV microparticles in rats. Drug Des Devel Ther. 2014 May 29;8:651-66. doi: 10.2147/DDDT.S60444. PMID: 24936127; PMCID: PMC4047837. 11: Khalil WF, Shaheen HM, Abdou RH. Ceftiofur pharmacokinetics in Nile tilapia Oreochromis niloticus after intracardiac and intramuscular administrations. Dis Aquat Organ. 2016 Aug 31;121(1):29-35. doi: 10.3354/dao03032. PMID: 27596857. 12: Yang F, Yang F, Wang H, Zhang CS, Song ZW, Shao HT, Zhang M. Pharmacokinetics of ceftiofur sodium in Peekapoo dogs following a single intravenous and subcutaneous injection. J Vet Pharmacol Ther. 2020 Jul;43(4):325-330. doi: 10.1111/jvp.12866. Epub 2020 Apr 12. Erratum in: J Vet Pharmacol Ther. 2020 Nov;43(6):616. PMID: 32281146. 13: Ambar N, Cox S, Hartup BK. PHARMACOKINETICS OF CEFTIOFUR CRYSTALLINE-FREE ACID ADMINISTERED VIA INTRAMUSCULAR INJECTION IN WHOOPING CRANES (GRUS AMERICANA). J Zoo Wildl Med. 2023 Mar;54(1):1-7. doi: 10.1638/2022-0058. PMID: 36971622. 14: Bonilla AG, Causeret L, Torrent-Crosa A. Pharmacokinetics of ceftiofur in the metacarpophalangeal joint after standing intravenous regional limb perfusion in horses. Can Vet J. 2021 Sep;62(9):975-981. PMID: 34475583; PMCID: PMC8360312. 15: Li XD, Chi SQ, Wu LY, Liu C, Sun T, Hong J, Chen X, Chen XG, Wang GS, Yu DJ. PK/PD modeling of Ceftiofur Sodium against Haemophilus parasuis infection in pigs. BMC Vet Res. 2019 Aug 1;15(1):272. doi: 10.1186/s12917-019-2008-4. PMID: 31370843; PMCID: PMC6676638. 16: Dutil L, Irwin R, Finley R, Ng LK, Avery B, Boerlin P, Bourgault AM, Cole L, Daignault D, Desruisseau A, Demczuk W, Hoang L, Horsman GB, Ismail J, Jamieson F, Maki A, Pacagnella A, Pillai DR. Ceftiofur resistance in Salmonella enterica serovar Heidelberg from chicken meat and humans, Canada. Emerg Infect Dis. 2010 Jan;16(1):48-54. doi: 10.3201/eid1601.090729. PMID: 20031042; PMCID: PMC2874360. 17: Foster DM, Jacob ME, Farmer KA, Callahan BJ, Theriot CM, Kathariou S, Cernicchiaro N, Prange T, Papich MG. Ceftiofur formulation differentially affects the intestinal drug concentration, resistance of fecal Escherichia coli, and the microbiome of steers. PLoS One. 2019 Oct 4;14(10):e0223378. doi: 10.1371/journal.pone.0223378. PMID: 31584976; PMCID: PMC6777789. 18: Durel L, Gallina G, Pellet T. Assessment of ceftiofur residues in cow milk using commercial screening test kits. Vet Rec Open. 2019 Apr 11;6(1):e000329. doi: 10.1136/vetreco-2018-000329. PMID: 31205727; PMCID: PMC6541105. 19: Gaire TN, Salas J, Dunmire KM, Paulk CB, Tokach MD, Nagaraja TG, Volkova VV. Faecal concentrations of ceftiofur metabolites in finisher pigs administered intramuscularly with ceftiofur. Vet Med Sci. 2021 Sep;7(5):1800-1806. doi: 10.1002/vms3.520. Epub 2021 May 15. PMID: 33991410; PMCID: PMC8464268. 20: Xie S, Zhang X, Luo W, Meng K, Chen D, Pan Y, Tao Y, Huang L, Liu Z, Wang Y, Yuan Z. Formulation, Characterization and Pharmacokinetics of Long-acting Ceftiofur Hydrochloride Suspension. Curr Drug Deliv. 2021;18(2):224-233. doi: 10.2174/1567201817666200903165119. PMID: 32885750.