CLT-28643 | CAS# 1153631-91-4 | Alpha5beta1-integrin inhibitor

MedKoo Cat#: 413199 | Name: CLT-28643

Description:

WARNING: This product is for research use only, not for human or veterinary use.

CLT-28643 is an Alpha5beta1-integrin inhibitor.

Chemical Structure

CLT-28643

CAS#1153631-91-4

Theoretical Analysis

MedKoo Cat#: 413199

Name: CLT-28643

CAS#: 1153631-91-4

Chemical Formula: C19H17N3O4

Exact Mass: 351.1219

Molecular Weight: 351.36

Elemental Analysis: C, 64.95; H, 4.88; N, 11.96; O, 18.21

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

CLT-28643; CLT28643; CLT 28643

IUPAC/Chemical Name

3-Quinolinecarboxylic acid, 4-((4-methoxyphenyl)amino)-6-((methylamino)carbonyl)-

InChi Key

TYORCOLIIIUMSE-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H17N3O4/c1-20-18(23)11-3-8-16-14(9-11)17(15(10-21-16)19(24)25)22-12-4-6-13(26-2)7-5-12/h3-10H,1-2H3,(H,20,23)(H,21,22)(H,24,25)

SMILES Code

O=C(C1=C(NC2=CC=C(OC)C=C2)C3=CC(C(NC)=O)=CC=C3N=C1)O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 351.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Schultheiss M, Schnichels S, Konrad EM, Bartz-Schmidt KU, Zahn G, Caldirola P, Fsadni MG, Caram-Lelham N, Spitzer MS. α5β1-Integrin inhibitor (CLT-28643) effective in rabbit trabeculectomy model. Acta Ophthalmol. 2017 Feb;95(1):e1-e9. doi: 10.1111/aos.13215. Epub 2016 Aug 31. PMID: 27576860. 2: Van Bergen T, Zahn G, Caldirola P, Fsadni M, Caram-Lelham N, Vandewalle E, Moons L, Stalmans I. Integrin α5β1 Inhibition by CLT-28643 Reduces Postoperative Wound Healing in a Mouse Model of Glaucoma Filtration Surgery. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6428-6439. doi: 10.1167/iovs.16-19751. PMID: 27893886.