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MedKoo Cat#: 413766 | Name: Dimetridazole HCl

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dimetridazole HCl is a compound used to treat histomoniasis in poultry.

Chemical Structure

Dimetridazole HCl
CAS#25332-20-1 (HCl)

Theoretical Analysis

MedKoo Cat#: 413766

Name: Dimetridazole HCl

CAS#: 25332-20-1 (HCl)

Chemical Formula: C5H8ClN3O2

Exact Mass:

Molecular Weight: 177.59

Elemental Analysis: C, 33.82; H, 4.54; Cl, 19.96; N, 23.66; O, 18.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
25332-20-1 (HCl) 93856-85-0 (mesilate) 551-92-8 (free base)
Synonym
Dimetridazole HCl; Dimetridazole hydrochloride
IUPAC/Chemical Name
1,2-Dimethyl-5-nitro-1H-imidazole monohydrochloride
InChi Key
UBQLFSIVOXQYEL-UHFFFAOYSA-N
InChi Code
InChI=1S/C5H7N3O2.ClH/c1-4-6-3-5(7(4)2)8(9)10;/h3H,1-2H3;1H
SMILES Code
O=[N+](C1=CN=C(C)N1C)[O-].[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 177.59 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zaghdoudi M, Fourcade F, Soutrel I, Floner D, Amrane A, Maghraoui-Meherzi H, Geneste F. Direct and indirect electrochemical reduction prior to a biological treatment for dimetridazole removal. J Hazard Mater. 2017 Aug 5;335:10-17. doi: 10.1016/j.jhazmat.2017.04.028. Epub 2017 Apr 9. PubMed PMID: 28414944. 2: Chen DM, Yu ZB, Sun L, Huang J, Gao LH, Li MJ. [Kinetics and Reactive Species Analysis of Dimetridazole Degradation by TiO2]. Huan Jing Ke Xue. 2015 Nov;36(11):4135-40. Chinese. PubMed PMID: 26911000. 3: Flores-Cano JV, Sánchez-Polo M, Messoud J, Velo-Gala I, Ocampo-Pérez R, Rivera-Utrilla J. Overall adsorption rate of metronidazole, dimetridazole and diatrizoate on activated carbons prepared from coffee residues and almond shells. J Environ Manage. 2016 Mar 15;169:116-25. doi: 10.1016/j.jenvman.2015.12.001. Epub 2015 Dec 28. PubMed PMID: 26731310. 4: Gadaj A, Cooper KM, Karoonuthaisiri N, Furey A, Danaher M. Determination of the persistence of dimetridazole, metronidazole and ronidazole residues in black tiger shrimp (Penaeus monodon) tissue and their stability during cooking. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2015;32(2):180-93. doi: 10.1080/19440049.2014.983997. Epub 2014 Dec 17. PubMed PMID: 25372355. 5: Hu C, Deng J, Zhao Y, Xia L, Huang K, Ju S, Xiao N. A novel core-shell magnetic nano-sorbent with surface molecularly imprinted polymer coating for the selective solid phase extraction of dimetridazole. Food Chem. 2014 Sep 1;158:366-73. doi: 10.1016/j.foodchem.2014.02.143. Epub 2014 Mar 6. PubMed PMID: 24731356. 6: Granja RH, Nino AM, Reche KV, Giannotti FM, de Lima AC, Wanschel AC, Salerno AG. Determination and confirmation of metronidazole, dimetridazole, ronidazole and their metabolites in bovine muscle by LC-MS/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2013;30(6):970-6. doi: 10.1080/19440049.2013.787653. Epub 2013 May 24. PubMed PMID: 23701281. 7: Sakamoto M, Takeba K, Sasamoto T, Kusano T, Hayashi H, Kanai S, Kanda M, Nagayama T. Determination of dimetridazole, metronidazole and ronidazole in salmon and honey by liquid chromatography coupled with tandem mass spectrometry. Shokuhin Eiseigaku Zasshi. 2011;52(1):51-8. PubMed PMID: 21383535. 8: Callait-Cardinal MP, Leroux S, Venereau E, Chauve CM, Le Pottier G, Zenner L. Incidence of histomonosis in turkeys in France since the bans of dimetridazole and nifursol. Vet Rec. 2007 Oct 27;161(17):581-5. PubMed PMID: 17965368. 9: Dernburg A, Rogier-Saderne MC, Chauve C, Zenner L. Consequences of the withdrawal of dimetridazole on intestinal parasitism in ducks. Vet Rec. 2005 Jan 29;156(5):148-50. PubMed PMID: 15717397. 10: Dalton JR. Inclusion of dimetridazole in gamebird feeds. Vet Rec. 2000 Apr 29;146(18):535. PubMed PMID: 11321219. 11: Sams MJ, Strutt PR, Barnes KA, Damant AP, Rose MD. Determination of dimetridazole, ronidazole and their common metabolite in poultry muscle and eggs by high performance liquid chromatography with UV detection and confirmatory analysis by atmospheric pressure chemical ionisation mass spectrometry. Analyst. 1998 Dec;123(12):2545-9. PubMed PMID: 10435296. 12: Laing PW. In-feed dimetridazole for gamebirds. Vet Rec. 1998 Jan 3;142(1):24. PubMed PMID: 9460224. 13: Cannavan A, Kennedy DG. Determination of dimetridazole in poultry tissues and eggs using liquid chromatography-thermospray mass spectrometry. Analyst. 1997 Sep;122(9):963-6. PubMed PMID: 9374025. 14: Ré JL, De Méo MP, Laget M, Guiraud H, Castegnaro M, Vanelle P, Duménil G. Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay. Mutat Res. 1997 Apr 29;375(2):147-55. PubMed PMID: 9202725. 15: Posyniak A, Semeniuk S, Zmudzki J, Niedzielska J, Biernacki B. Tissue concentration of dimetridazole in laying hens. Food Addit Contam. 1996 Nov-Dec;13(8):871-7. PubMed PMID: 8950108. 16: Dalton P. Use of dimetridazole in gamebirds. Vet Rec. 1996 Oct 19;139(16):399. PubMed PMID: 8913016. 17: Inghelbrecht S, Vermeersch H, Ronsmans S, Remon JP, DeBacker P, Vercruysse J. Pharmacokinetics and anti-trichomonal efficacy of a dimetridazole tablet and water-soluble powder in homing pigeons (Columba livia). J Vet Pharmacol Ther. 1996 Feb;19(1):62-7. PubMed PMID: 8992028. 18: Posyniak A, Semeniuk S, Zmudzki J, Niedzielska J, Biernacki B. Residues of dimetridazole in eggs after treatment of laying hens. Vet Res Commun. 1996;20(2):167-74. PubMed PMID: 8711897. 19: EC bans use of dimetridazole in food animals. Vet Rec. 1995 Sep 2;137(10):230. PubMed PMID: 8533212. 20: Coles BH. Dimetridazole dose for birds. Vet Rec. 1992 Jan 11;130(2):40. PubMed PMID: 1542990.