Synonym
Diflucortolone (free base); Diflucortolona; Diflucortolonum
IUPAC/Chemical Name
Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-
InChi Key
OGPWIDANBSLJPC-RFPWEZLHSA-N
InChi Code
InChI=1S/C22H28F2O4/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-21(15,3)22(14,24)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
SMILES Code
C[C@@]12[C@@H](C(CO)=O)[C@H](C)C[C@@]1([H])[C@]3([H])C[C@H](F)C4=CC(C=C[C@]4(C)[C@@]3(F)[C@@H](O)C2)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
394.46
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Hoppe G. Diflucortolone valerate. Asian experience. Drugs. 1988;36 Suppl 5:24-33. doi: 10.2165/00003495-198800365-00006. PMID: 3254827.
2: Veraldi S, Schianchi R, Esposito L, Pontini P, Nazzaro G. Treatment of postscabies prurigo with diflucortolone and chlorquinaldol in a group of African refugees. Trop Doct. 2019 Oct;49(4):268-270. doi: 10.1177/0049475519855577. Epub 2019 Jun 18. PMID: 31208292.
3: Veraldi S, Schianchi R, Pontini P, Gorani A. The association of isoconazole- diflucortolone in the treatment of pediatric tinea corporis. J Dermatolog Treat. 2018 Mar;29(2):200-201. doi: 10.1080/09546634.2017.1360988. Epub 2017 Sep 19. PMID: 28753055.
4: Cabras M, Gambino A, Broccoletti R, Lodi G, Arduino PG. Treatment of angular cheilitis: A narrative review and authors' clinical experience. Oral Dis. 2019 Aug 29. doi: 10.1111/odi.13183. Epub ahead of print. PMID: 31464357.
5: Haviv R, Capua M, Amir J, Harel L. Cutaneous polyarteritis nodosa successfully treated with topical diflucortolone valerate: a case report & review of the literature. Pediatr Rheumatol Online J. 2014 Oct 10;12:46. doi: 10.1186/1546-0096-12-46. PMID: 25328491; PMCID: PMC4200200.
6: Brunner N, Yawalkar S. A double-blind, multicenter, parallel-group trial with 0.05% halobetasol propionate ointment versus 0.1% diflucortolone valerate ointment in patients with severe, chronic atopic dermatitis or lichen simplex chronicus. J Am Acad Dermatol. 1991 Dec;25(6 Pt 2):1160-3. doi: 10.1016/0190-9622(91)70317-u. PMID: 1757609.
7: Geraldez MC, Carreon-Gavino M, Hoppe G, Costales A. Diflucortolone valerate ointment with and without occlusion in lichen simplex chronicus. Int J Dermatol. 1989 Nov;28(9):603-4. doi: 10.1111/j.1365-4362.1989.tb02538.x. PMID: 2583907.
8: Abdel-Salam FS, Mahmoud AA, Ammar HO, Elkheshen SA. Nanostructured lipid carriers as semisolid topical delivery formulations for diflucortolone valerate. J Liposome Res. 2017 Mar;27(1):41-55. doi: 10.3109/08982104.2016.1149866. Epub 2016 Mar 9. PMID: 26956098.
9: Czaika VA. Superficial dermatomycoses worldwide: multinational treatment experience with a combination of isoconazole nitrate and diflucortolone valerate. Introduction. Mycoses. 2008 Sep;51 Suppl 4:1. doi: 10.1111/j.1439-0507.2008.01604.x. PMID: 18783558.
10: Täuber U, Weiss C, Matthes H. Does salicylic acid increase the percutaneous absorption of diflucortolone-21-valerate? Skin Pharmacol. 1993;6(4):276-81. doi: 10.1159/000211150. PMID: 8198813.
