MedKoo Cat#: 124246 | Name: SIRT5 inhibitor 5
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

SIRT5 inhibitor 5 is a potent SIRT5 inhibitor with an IC50 value of 0.21 µM.

Chemical Structure

SIRT5 inhibitor 5
CAS#2883730-60-5

Theoretical Analysis

MedKoo Cat#: 124246

Name: SIRT5 inhibitor 5

CAS#: 2883730-60-5

Chemical Formula: C21H14ClN3O3S

Exact Mass: 423.0444

Molecular Weight: 423.87

Elemental Analysis: C, 59.51; H, 3.33; Cl, 8.36; N, 9.91; O, 11.32; S, 7.56

Price and Availability

Size Price Availability Quantity
200mg USD 1,450.00 2 Weeks
500mg USD 2,850.00 2 Weeks
1g USD 4,250.00 2 Weeks
2g USD 6,450.00 2 Weeks
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Related CAS #
No Data
Synonym
SIRT5 Inhibitor 5; SIRT5 inhibitor-5; SIRT5-inhibitor-5; SIRT-5inhibitor 5
IUPAC/Chemical Name
(E)-4-((1-(4-(4-chlorophenyl)thiazol-2-yl)-3-methyl-5-oxo-1,5-dihydro-4H-pyrazol-4-ylidene)methyl)benzoic acid
InChi Key
BASVBEFRHZKYIH-LICLKQGHSA-N
InChi Code
InChI=1S/C21H14ClN3O3S/c1-12-17(10-13-2-4-15(5-3-13)20(27)28)19(26)25(24-12)21-23-18(11-29-21)14-6-8-16(22)9-7-14/h2-11H,1H3,(H,27,28)/b17-10+
SMILES Code
CC1=NN(C(/C1=C/C2=CC=C(C=C2)C(O)=O)=O)C3=NC(C4=CC=C(C=C4)Cl)=CS3
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 423.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Yao J, Yin Y, Han H, Chen S, Zheng Y, Liang B, Wu M, Shu K, Debnath B, Lombard DB, Wang Q, Cheng K, Neamati N, Liu Y. Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors. Eur J Med Chem. 2023 Feb 5;247:115024. doi: 10.1016/j.ejmech.2022.115024. Epub 2022 Dec 16. PMID: 36543033.