Synonym
Diflucortolone 21-valerate; Diflucortolone 21 valerate;
IUPAC/Chemical Name
2-((6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl pentanoate
InChi Key
HHJIUUAMYGBVSD-YTFFSALGSA-N
InChi Code
InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1
SMILES Code
F[C@]12[C@]([H])([C@]3([C@]([C@@H](C(COC(CCCC)=O)=O)[C@H](C)C3)(C)C[C@@H]2O)[H])C[C@H](F)C([C@]1(C)C=C4)=CC4=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
|
Solvent |
mg/mL |
mM |
comments |
| Solubility |
| Soluble in DMSO |
0.0 |
100.00 |
|
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.
Preparing Stock Solutions
The following data is based on the
product
molecular weight
478.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Henz BM, Jablonska S, van de Kerkhof PC, Stingl G, Blaszczyk M, Vandervalk PG, Veenhuizen R, Muggli R, Raederstorff D. Double-blind, multicentre analysis of the efficacy of borage oil in patients with atopic eczema. Br J Dermatol. 1999 Apr;140(4):685-8. doi: 10.1046/j.1365-2133.1999.02771.x. PMID: 10233322.
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6: Junghans C, Kuhlwein A, Hausen BM. Mehrfachsensibilisierung gegen topisch angewandte Kortikosteroide [Multiple sensitization to topically used corticosteroids]. Derm Beruf Umwelt. 1986 May-Jun;34(3):68-70. German. PMID: 2943572.
7: Täuber U. Verfügbarkeit von Diflucortolon-21-valerat in der menschlichen Haut [Biologic availability of diflucortolone-21-valerate in human skin]. Arzneimittelforschung. 1983;33(10):1503-7. German. PMID: 6686053.
8: Weitgasser H, Herms E. Vergleichende klinische untersuchungen mit dem neuen Antimykotikum Isoconazolnitrat und seiner Kombination mit Diflucortolon-21-valerat bei entzündlichen und ekzematisierten Dermatomykosen [Comparative clinical investigations with the new antimycotic agent isoconazole nitrate and its combination with diflucortolone-21-valerate in the case of inflammatory and eczematised dermatomycoses]. Mykosen. 1979 Jun;22(6):177-83. German. PMID: 379640.
9: Wendt H, Kessler J. Antimikrobielle Wirksamkeit des Breitspektrum- Antimykotikums Isoconazolnitrat im Humanversuch [Antimicrobial activity of the broad spectrum antimycotic isoconazole nitrate in humans (author's transl)]. Arzneimittelforschung. 1979;29(5):846-8. German. PMID: 582987.
10: Grejs J. Vergleichende Prüfung von Diflucortolon-21-valerat Creme und Hydrocortison-17-butyrat Creme bei Hautkranken [Comparative testing of diflucortolon-21-valerate creme and hydrocortisone-17-butyrate creme in patients with dermatoses]. Ther Ggw. 1978 Dec;117(12):1930-7. German. PMID: 725810.
