Clavulone II | CAS# 85700-43-2 | antineoplastic

MedKoo Cat#: 413058 | Name: Clavulone II

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Clavulone II is a clavulone, a methyl ester and an acetate ester. It has a role as an antineoplastic agent.

Chemical Structure

Clavulone II

CAS#85700-43-2

Theoretical Analysis

MedKoo Cat#: 413058

Name: Clavulone II

CAS#: 85700-43-2

Chemical Formula: C25H34O7

Exact Mass: 446.2305

Molecular Weight: 446.54

Elemental Analysis: C, 67.24; H, 7.68; O, 25.08

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Clavulone II

IUPAC/Chemical Name

Prosta-5,7,10,14-tetraen-1-oic acid, 4,12-bis(acetyloxy)-9-oxo-, methyl ester, (4R,5E,7E,12alpha,14Z)-

InChi Key

QXSYLWTUKSQQCP-LNGUFEKVSA-N

InChi Code

InChI=1S/C25H34O7/c1-5-6-7-8-9-10-17-25(32-20(3)27)18-16-23(28)22(25)13-11-12-21(31-19(2)26)14-15-24(29)30-4/h9-13,16,18,21H,5-8,14-15,17H2,1-4H3/b10-9-,12-11+,22-13-/t21-,25+/m0/s1

SMILES Code

CCCCC/C=C\C[C@]1(OC(C)=O)/C(C(C=C1)=O)=C\C=C\[C@H](OC(C)=O)CCC(OC)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 446.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Huang YC, Guh JH, Shen YC, Teng CM. Investigation of anticancer mechanism of clavulone II, a coral cyclopentenone prostaglandin analog, in human acute promyelocytic leukemia. J Biomed Sci. 2005;12(2):335-45. doi: 10.1007/s11373-005-3009-9. PMID: 15920677. 2: Bader T, Yamada Y, Ankel H. Antiviral activity of the prostanoid clavulone II against vesicular stomatitis virus. Antiviral Res. 1991 Dec;16(4):341-55. doi: 10.1016/0166-3542(91)90048-v. PMID: 1663734. 3: Honda A, Mori Y, Yamada Y, Nakaike S, Hayashi H, Otomo S. Prolonged survival time of sarcoma 180-bearing mice treated with lipid microspheres-entrapped antitumor marine coral prostanoids. Res Commun Chem Pathol Pharmacol. 1988 Sep;61(3):413-6. PMID: 3187200. 4: Roulland E, Monneret C, Florent JC, Bennejean C, Renard P, Léonce S. Enantioselective synthesis of 12-amino alkylidenecyclopentenone prostaglandins. J Org Chem. 2002 Jun 28;67(13):4399-406. doi: 10.1021/jo010481k. PMID: 12076134.