MedKoo Cat#: 413695 | Name: Dichlorisone (free base)

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dichlorisone (free base) is a synthetic glucocorticoid corticosteroid

Chemical Structure

 Dichlorisone (free base)
Dichlorisone (free base)
CAS#7008-26-6 (free base)

Theoretical Analysis

MedKoo Cat#: 413695

Name: Dichlorisone (free base)

CAS#: 7008-26-6 (free base)

Chemical Formula: C21H26Cl2O4

Exact Mass: 412.1208

Molecular Weight: 413.34

Elemental Analysis: C, 61.02; H, 6.34; Cl, 17.15; O, 15.48

Price and Availability

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Synonym
Dichlorisone (free base); Diclorisona; Dichlorisonum
IUPAC/Chemical Name
(8S,9R,10S,11S,13S,14S,17R)-9,11-dichloro-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
InChi Key
CZJXBZPJABCCRQ-BULBTXNYSA-N
InChi Code
InChI=1S/C21H26Cl2O4/c1-18-7-5-13(25)9-12(18)3-4-15-14-6-8-20(27,17(26)11-24)19(14,2)10-16(22)21(15,18)23/h5,7,9,14-16,24,27H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1
SMILES Code
C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1CC[C@@]2(C(CO)=O)O)CCC4=CC(C=C[C@]34C)=O)Cl)Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 413.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: ROBINSON HM Jr. Dichlorisone: a "topical" steroid. South Med J. 1960 Oct;53:1268-9. doi: 10.1097/00007611-196010000-00013. PMID: 13742295. 2: GRIBOFF SI. DICHLORISONE TREATMENT OF ALOPECIA. Med Times. 1963 Nov;91:1101-11. PMID: 14052165. 3: Gruol DJ, Bourgeois S. Chemosensitizing steroids: glucocorticoid receptor agonists capable of inhibiting P-glycoprotein function. Cancer Res. 1997 Feb 15;57(4):720-7. PMID: 9044851. 4: Luo Y, Uboh CE, Soma LR, Guan FY, Rudy JA, Tsang DS. Simultaneous analysis of twenty-one glucocorticoids in equine plasma by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2005;19(10):1245-56. doi: 10.1002/rcm.1916. PMID: 15838928. 5: GANT JQ Jr. Dichlorisone in the management of poison ivy dermatitis. Med Ann Dist Columbia. 1961 May;30:267-8. PMID: 13703386. 6: JEANDIDIER P. L'AC'ETATE DE DICHLORISONE (VISODERM) EN TH'ERAPEUTIQUE DERMATOLOGIQUE LOCALE [DICHLORISONE ACETATE (VISODERM) IN LOCAL DERMATOLOGIC THERAPHY]. Ann Med Nancy. 1964 Aug-Sep;3:1062-5. French. PMID: 14229556. 7: SPIRANDELLI E, MIRANDE JL, GORI L. [Experience with a new steroid (dichlorisone) for topical ise in proctology]. Sem Med. 1963 Apr 18;122:663-6. Spanish. PMID: 13990175. 8: Griboff SI, Futterweit W. Effects of new 9,11-dihalogenated corticosteroids in various types of alopecia. II. Pituitary-adrenal responsiveness in patients treated with 16 alpha-methyl-dichlorisone alcohol. J Mt Sinai Hosp N Y. 1967 Mar-Apr;34(2):130-4. PMID: 5232041. 9: WEREIDE K. [Plastic covering for corticosteroid salves in psoriasis. Therapeutic trials with fluocinolone acetonide, triamcinolone acetonide and dichlorisone acetate]. Tidsskr Nor Laegeforen. 1963 Jun 15;83:1034-7. Norwegian. PMID: 13999986.