Pelcitoclax, also known as APG 1252 and BM1251, is a potent and selective Bcl-2/Bcl-XL inhibitor. APG-1252 A Bcl-2 homology (BH)-3 mimetic and selective inhibitor of the anti-apoptotic proteins B-cell lymphoma 2 (Bcl-2) and Bcl-XL, with potential pro-apoptotic and antineoplastic activities. Upon administration, Bcl-2/Bcl-XL inhibitor APG-1252 specifically binds to and inhibits the activity of the pro-survival proteins Bcl-2 and Bcl-XL. This restores apoptotic processes and inhibits cell proliferation in Bcl-2/Bcl-XL-dependent tumor cells.
MedKoo Cat#: 207133
Name: Pelcitoclax
CAS#: 1619923-36-2 (free base)
Chemical Formula: C57H66ClF4N6O11PS4
Exact Mass: 1280.3035
Molecular Weight: 1281.84
Elemental Analysis: C, 53.41; H, 5.19; Cl, 2.77; F, 5.93; N, 6.56; O, 13.73; P, 2.42; S, 10.00
The following data is based on the product molecular weight 1,281.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
