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MedKoo Cat#: 573366 | Name: AZ-DF 265

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AZ-DF 265 is a hypoglycaemic drug which stimulates insulin release. AZ-DF-265 inhibits ATP-sensitive potassium channels and displaces [3H]-glibenclamide from the sulphonylurea receptor.

Chemical Structure

AZ-DF 265
AZ-DF 265
CAS#83901-40-0

Theoretical Analysis

MedKoo Cat#: 573366

Name: AZ-DF 265

CAS#: 83901-40-0

Chemical Formula: C27H28N2O3

Exact Mass: 428.2100

Molecular Weight: 428.53

Elemental Analysis: C, 75.68; H, 6.59; N, 6.54; O, 11.20

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
AZ-DF 265, AZ-DF-265, (-)-AZ-DF-265, (-)-AZ-DF 265
IUPAC/Chemical Name
Benzoic acid, 4-(2-oxo-2-((phenyl(2-(1-piperidinyl)phenyl)methyl)amino)ethyl)-
InChi Key
KLYSDWDGUUKBSX-UHFFFAOYSA-N
InChi Code
1S/C27H28N2O3/c30-25(19-20-13-15-22(16-14-20)27(31)32)28-26(21-9-3-1-4-10-21)23-11-5-6-12-24(23)29-17-7-2-8-18-29/h1,3-6,9-16,26H,2,7-8,17-19H2,(H,28,30)(H,31,32)
SMILES Code
c1ccc(cc1)C(c2ccccc2N3CCCCC3)NC(=O)Cc4ccc(cc4)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 428.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ronner P, Hang TL, Kraebber MJ, Higgins TJ. Effect of the hypoglycaemic drug (-)-AZ-DF-265 on ATP-sensitive potassium channels in rat pancreatic beta-cells. Br J Pharmacol. 1992 Jun;106(2):250-5. PubMed PMID: 1393260; PubMed Central PMCID: PMC1907504. 2: Garrino MG, Henquin JC. Highly potent and stereoselective effects of the benzoic acid derivative AZ-DF 265 on pancreatic beta-cells. Br J Pharmacol. 1988 Jan;93(1):61-8. PubMed PMID: 3280060; PubMed Central PMCID: PMC1853762.