MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 464328 | Name: Barnidipine-d5 HCl
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Barnidipine-d5 HCl is intended for use as an internal standard for the quantification of barnidipine by GC- or LC-MS. Barnidipine is a dihydropyridine calcium channel blocker that has an IC50 value of 0.35 nM in potassium-induced tonic contraction of pig coronary artery. It demonstrates antihypertensive activity by reducing peripheral vascular resistance. It decreases blood pressure in spontaneously hypertensive rats when administered orally at 1 and 3 mg/kg per day. Formulations containing barnidipine have been used in the treatment of hypertension.

Chemical Structure

Barnidipine-d5 HCl
Barnidipine-d5 HCl
CAS#Barnidipine-d5 HCl

Theoretical Analysis

MedKoo Cat#: 464328

Name: Barnidipine-d5 HCl

CAS#: Barnidipine-d5 HCl

Chemical Formula: C27H25D5ClN3O6

Exact Mass: 0.0000

Molecular Weight: 533.03

Elemental Analysis: C, 60.84; H, 6.62; Cl, 6.65; N, 7.88; O, 18.01

Price and Availability

Size Price Availability Quantity
1mg USD 450.00 2 Weeks
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
104713-75-9 (free base) 104757-53-1 (HCl) Barnidipine-d5 HCl
Synonym
Barnidipine-d5 HCl; Barnidipine d5 HCl; YM-09730-5-d5; YM09730-5-d5; YM 09730-5-d5;
IUPAC/Chemical Name
3-methyl 5-((S)-1-((phenyl-d5)methyl)pyrrolidin-3-yl) (S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride
InChi Key
XEMPUKIZUCIZEY-MWQBNHTBSA-N
InChi Code
InChI=1S/C27H29N3O6.ClH/c1-17-23(26(31)35-3)25(20-10-7-11-21(14-20)30(33)34)24(18(2)28-17)27(32)36-22-12-13-29(16-22)15-19-8-5-4-6-9-19;/h4-11,14,22,25,28H,12-13,15-16H2,1-3H3;1H/t22-,25-;/m0./s1/i4D,5D,6D,8D,9D;
SMILES Code
CC1=C([C@@H](C2=CC([N+]([O-])=O)=CC=C2)C(C(OC)=O)=C(N1)C)C(O[C@@H]3CN(CC3)CC4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H])=O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 533.03 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Baby K, Maity S, Mehta CH, Suresh A, Nayak UY, Nayak Y. Targeting SARS-CoV-2 Main Protease: A Computational Drug Repurposing Study. Arch Med Res. 2021 Jan;52(1):38-47. doi: 10.1016/j.arcmed.2020.09.013. Epub 2020 Sep 17. PMID: 32962867; PMCID: PMC7498210. 2: Mulder-Wildemors LGM, Heringa M, Floor-Schreudering A, Jansen PAF, Bouvy ML. Reducing Inappropriate Drug Use in Older Patients by Use of Clinical Decision Support in Community Pharmacy: A Mixed-Methods Evaluation. Drugs Aging. 2020 Feb;37(2):115-123. doi: 10.1007/s40266-019-00728-y. PMID: 31782128. 3: Daltaban IS, Misir S, Turksoy VA, Ak H, Cakir E. The effects of barnidipine on an experimental ischemia reperfusion model of spinal cord injury and comparison with methyl prednisolone. North Clin Istanb. 2018 Oct 9;6(2):103-109. doi: 10.14744/nci.2018.89411. PMID: 31297474; PMCID: PMC6593922. 4: Ikemura N, Yamaori S, Kobayashi C, Kamijo S, Murayama N, Yamazaki H, Ohmori S. Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine. Chem Biol Interact. 2019 Jun 1;306:1-9. doi: 10.1016/j.cbi.2019.04.005. Epub 2019 Apr 6. PMID: 30965050. 5: Haq SF, Shanbhag AP, Karthikeyan S, Hassan I, Thanukrishnan K, Ashok A, Sukumaran S, Ramaswamy S, Bharatham N, Datta S, Samant S, Katagihallimath N. A strategy to identify a ketoreductase that preferentially synthesizes pharmaceutically relevant (S)-alcohols using whole-cell biotransformation. Microb Cell Fact. 2018 Dec 3;17(1):192. doi: 10.1186/s12934-018-1036-2. PMID: 30509260; PMCID: PMC6276252. 6: Gosho M. Risk of Hypoglycemia After Concomitant Use of Antidiabetic, Antihypertensive, and Antihyperlipidemic Medications: A Database Study. J Clin Pharmacol. 2018 Oct;58(10):1324-1331. doi: 10.1002/jcph.1147. Epub 2018 May 15. PMID: 29762878. 7: Ozturk N, Ozturk D, Pala-Kara Z, Okyar A. Pharmacokinetics of talinolol is modified by barnidipine: implication of P-glycoprotein modulation. Pharmazie. 2017 Jan 10;72(1):29-34. doi: 10.1691/ph.2017.6786. PMID: 29441894. 8: Lins R, De Vries C. Barnidipine Real-Life Efficacy and Tolerability in Arterial Hypertension: Results from Younger and Older Patients in the BASIC-HT Study. Open Cardiovasc Med J. 2017 Nov 17;11:120-132. doi: 10.2174/1874192401711010120. PMID: 29290834; PMCID: PMC5721309. 9: Tocci G, Desideri G, Roca E, Calcullo C, Crippa M, De Luca N, Gaudio GV, Lonati LM, Orselli L, Scuteri A, Vulpis V, Acone B, Zaninelli A; THYPERevolution Steering Committee. How to Improve Effectiveness and Adherence to Antihypertensive Drug Therapy: Central Role of Dihydropyridinic Calcium Channel Blockers in Hypertension. High Blood Press Cardiovasc Prev. 2018 Mar;25(1):25-34. doi: 10.1007/s40292-017-0242-z. Epub 2017 Dec 2. PMID: 29197935; PMCID: PMC5842506. 10: Lins R, Haerden Y, de Vries C. Replacement of Amlodipine and Lercanidipine by Barnidipine: Tolerability and Effectiveness in a Real-Life Study. High Blood Press Cardiovasc Prev. 2017 Mar;24(1):29-36. doi: 10.1007/s40292-016-0177-9. PMID: 28058623. 11: Derosa G, Mugellini A, Pesce RM, D'Angelo A, Maffioli P. Barnidipine compared to lercanidipine in addition to losartan on endothelial damage and oxidative stress parameters in patients with hypertension and type 2 diabetes mellitus. BMC Cardiovasc Disord. 2016 Apr 12;16:66. doi: 10.1186/s12872-016-0237-z. PMID: 27068332; PMCID: PMC4828780. 12: Crippa G, Zabzuni D, Cassi A, Bravi E. Effect of bedtime dosing of barnidipine hydrochloride in non-dipper hypertensive patients with obstructive sleep apnoea not treated with continuous positive airway pressure. Eur Rev Med Pharmacol Sci. 2016;20(2):339-44. PMID: 26875906. 13: Derosa G, Mugellini A, Pesce RM, D'Angelo A, Maffioli P. Perindopril and barnidipine alone or combined with simvastatin on hepatic steatosis and inflammatory parameters in hypertensive patients. Eur J Pharmacol. 2015 Nov 5;766:31-6. doi: 10.1016/j.ejphar.2015.09.030. Epub 2015 Sep 25. PMID: 26407654. 14: Derosa G, Mugellini A, Querci F, Franzetti I, Pesce RM, D'Angelo A, Maffioli P. Barnidipine or Lercanidipine on Echocardiographic Parameters in Hypertensive, Type 2 Diabetics with Left Ventricular Hypertrophy: A Randomized Clinical Trial. Sci Rep. 2015 Aug 5;5:12603. doi: 10.1038/srep12603. PMID: 26243165; PMCID: PMC4525144. 15: Alp Yildirim FI, Eker Kizilay D, Ergin B, Balci Ekmekçi Ö, Topal G, Kucur M, Demirci Tansel C, Uydeş Doğan BS. Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats. Eur J Pharmacol. 2015 Oct 5;764:433-442. doi: 10.1016/j.ejphar.2015.07.033. Epub 2015 Jul 14. PMID: 26187312. 16: Derosa G, Querci F, Franzetti I, Dario Ragonesi P, D'Angelo A, Maffioli P. Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus. Hypertens Res. 2015 Oct;38(10):690-4. doi: 10.1038/hr.2015.57. Epub 2015 May 21. PMID: 25994603. 17: Lins R, Marckx P, Vandebeek R, Vanhoutvinck C, Neuville O. Barnidipine real- life tolerability in arterial hypertension: results from the BASIC-HT study. Acta Clin Belg. 2015 Aug;70(4):244-50. doi: 10.1179/2295333715Y.0000000012. Epub 2015 Mar 27. PMID: 25816195. 18: Magrini N, Formoso G, Capelli O, Maestri E, Nonino F, Paltrinieri B, Del Giovane C, Voci C, Magnano L, Daya L, Marata AM; INDRA-NET study group. Long term effectiveness on prescribing of two multifaceted educational interventions: results of two large scale randomized cluster trials. PLoS One. 2014 Oct 17;9(10):e109915. doi: 10.1371/journal.pone.0109915. PMID: 25329386; PMCID: PMC4201458. 19: Cheng ZG, Dai XY, Li LW, Wan Q, Ma X, Xiang GY. Synthesis and characterization of impurities of barnidipine hydrochloride, an antihypertensive drug substance. Molecules. 2014 Jan 21;19(1):1344-52. doi: 10.3390/molecules19011344. PMID: 24451253; PMCID: PMC6270734. 20: Ioele G, De Luca M, Ragno G. Photostability of barnidipine in combined cyclodextrin-in-liposome matrices. Future Med Chem. 2014 Jan;6(1):35-43. doi: 10.4155/fmc.13.187. PMID: 24358946.

View History

Dacuronium

Dacuronium

QM295

QM295

C.I. 63010

C.I. 63010

Delmopinol acetate

Delmopinol acetate

Bakuchicin

Bakuchicin

QUCHIC

QUCHIC