Adefovir monophosphate | CAS# 129556-87-2 | Biochemical

MedKoo Cat#: 573944 | Name: Adefovir monophosphate

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Adefovir monophosphate is an antiviral acyclic nucleoside phosphonate (ANP) analog with activity against hepatitis B virus (HBV), herpes virus, and human immunodeficiency virus (HIV). It is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) that works by blocking reverse transcriptase for the treatment of hepatitis B. Adefovir dipivoxil is not effective against HIV-1.

Chemical Structure

Adefovir monophosphate

CAS#129556-87-2 (monophosphate)

Theoretical Analysis

MedKoo Cat#: 573944

Name: Adefovir monophosphate

CAS#: 129556-87-2 (monophosphate)

Chemical Formula: C8H13N5O7P2

Exact Mass: 353.0290

Molecular Weight: 353.17

Elemental Analysis: C, 27.21; H, 3.71; N, 19.83; O, 31.71; P, 17.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

142340-99-6 (dipivoxil) 106941-25-7 (free acid) 129556-87-2 (monophosphate)

Synonym

Adefovir monophosphate, Adefovir phosphate

IUPAC/Chemical Name

((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphonic phosphoric anhydride

InChi Key

VQIHLCFUFNQXPS-UHFFFAOYSA-N

InChi Code

1S/C8H13N5O7P2/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-19-5-21(14,15)20-22(16,17)18/h3-4H,1-2,5H2,(H,14,15)(H2,9,10,11)(H2,16,17,18)

SMILES Code

c1nc(c2c(n1)n(cn2)CCOCP(=O)(O)OP(=O)(O)O)N

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 353.17 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Lin RZ, Sun PJ, Tao Q, Yao J, Chen JM, Lu TB. Mechanism study on stability enhancement of adefovir dipivoxil by cocrystallization: Degradation kinetics and structure-stability correlation. Eur J Pharm Sci. 2015 Oct 10. pii: S0928-0987(15)30035-X. doi: 10.1016/j.ejps.2015.10.006. [Epub ahead of print] PubMed PMID: 26462447. 2: Ning HB, Li K, Li W, Ding GQ, Xiao EH, Mao ZS, Kang Y, Shang J. [Adefovir dipivoxil effects on and related factors of blood phosphorus metabolism in patients with chronic hepatitis B]. Zhonghua Gan Zang Bing Za Zhi. 2015 Aug 20;23(8):590-3. doi: 10.3760/cma.j.issn.1007-3418.2015.08.007. Chinese. PubMed PMID: 26447622. 3: Gu J, Sun R, Shen S, Yu Z. The curative effect of adefovir dipivoxil treating HBeAg negative chronic hepatitis B and treating HBeAg positive chronic hepatitis B combining interferon α-2b. Pak J Pharm Sci. 2015 Jul;28(4 Suppl):1493-7. PubMed PMID: 26431662. 4: Zhu H, Yuan X, Tang L, Hu P, Cai D, Ren F, Huang W. [Clinical analysis of Fanconi syndrome induced by adefovir dipivoxil]. Zhonghua Gan Zang Bing Za Zhi. 2015 Apr;23(4):302-3. Chinese. PubMed PMID: 26427083.