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MedKoo Cat#: 413566 | Name: Desethylamiodarone HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desethylamiodarone HCl is the salt form of Desethylamiodarone, a metabolite of amiodarone.

Chemical Structure

Desethylamiodarone HCl
Desethylamiodarone HCl
CAS#96027-74-6 (HCl)

Theoretical Analysis

MedKoo Cat#: 413566

Name: Desethylamiodarone HCl

CAS#: 96027-74-6 (HCl)

Chemical Formula: C23H26ClI2NO3

Exact Mass: 0.0000

Molecular Weight: 653.72

Elemental Analysis: C, 42.26; H, 4.01; Cl, 5.42; I, 38.83; N, 2.14; O, 7.34

Price and Availability

Size Price Availability Quantity
25mg USD 350.00 2 Weeks
50mg USD 650.00 2 Weeks
100mg USD 950.00 2 Weeks
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Related CAS #
83409-32-9 (free base) 96027-74-6 (HCl)
Synonym
Desethylamiodarone HCl; Desethylamiodarone hydrochloride; metabolite of amiodarone; Desethyl Amiodarone Hydrochloride; Desethyl Amiodarone HCl;
IUPAC/Chemical Name
(2-Butyl-1-benzofuran-3-yl)-(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone hydrochloride
InChi Key
OCQPMJVGWGJLLG-UHFFFAOYSA-N
InChi Code
InChI=1S/C23H25I2NO3.ClH/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2;/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3;1H
SMILES Code
O=C(C1=C(CCCC)OC2=C1C=CC=C2)C3=CC(I)=C(OCCNCC)C(I)=C3.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 653.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Colvin RA, Oibo JA, Allen RA, Tyler L, Leek D. Interaction of amiodarone and desethylamiodarone with the cardiac muscarinic receptor in vitro. J Mol Cell Cardiol. 1989 May;21(5):453-60. doi: 10.1016/0022-2828(89)90785-2. PMID: 2778804. 2: Matuskova Z, Anzenbacher P, Vecera R, Siller M, Tlaskalova-Hogenova H, Strojil J, Anzenbacherova E. Effect of Lactobacillus casei on the Pharmacokinetics of Amiodarone in Male Wistar Rats. Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):29-36. doi: 10.1007/s13318-015-0315-0. PMID: 26797809. 3: Karkhanis A, Tram NDT, Chan ECY. Effects of dronedarone, amiodarone and their active metabolites on sequential metabolism of arachidonic acid to epoxyeicosatrienoic and dihydroxyeicosatrienoic acids. Biochem Pharmacol. 2017 Dec 15;146:188-198. doi: 10.1016/j.bcp.2017.09.012. Epub 2017 Sep 25. PMID: 28958841. 4: Svensson CK, Liu LL, Knowlton PW. Effect of amiodarone and desethylamiodarone on the pharmacokinetics of antipyrine in the rat. Pharm Res. 1987 Jun;4(3):251-4. doi: 10.1023/a:1016468430618. PMID: 3509291. 5: Karkhanis A, Lam HY, Venkatesan G, Koh SK, Chai CL, Zhou L, Hong Y, Kojodjojo P, Chan EC. Multiple modes of inhibition of human cytochrome P450 2J2 by dronedarone, amiodarone and their active metabolites. Biochem Pharmacol. 2016 May 1;107:67-80. doi: 10.1016/j.bcp.2016.03.005. Epub 2016 Mar 10. PMID: 26972388. 6: Matuskova Z, Anzenbacherova E, Vecera R, Tlaskalova-Hogenova H, Kolar M, Anzenbacher P. Administration of a probiotic can change drug pharmacokinetics: effect of E. coli Nissle 1917 on amidarone absorption in rats. PLoS One. 2014 Feb 5;9(2):e87150. doi: 10.1371/journal.pone.0087150. PMID: 24505278; PMCID: PMC3914806. 7: Nolan PE Jr, Marcus FI, Karol MD, Hoyer GL, Gear K. Effect of phenytoin on the clinical pharmacokinetics of amiodarone. J Clin Pharmacol. 1990 Dec;30(12):1112-9. doi: 10.1002/j.1552-4604.1990.tb01854.x. PMID: 2273084. 8: Weir SJ, Ueda CT. Amiodarone pharmacokinetics. I. Acute dose-dependent disposition studies in rats. J Pharmacokinet Biopharm. 1986 Dec;14(6):601-13. doi: 10.1007/BF01067966. PMID: 3820092. 9: Roca J, Heras M, Rodriguez-Roisin R, Magriñà J, Xaubet A, Sanz G. Pulmonary complications after long term amiodarone treatment. Thorax. 1992 May;47(5):372-6. doi: 10.1136/thx.47.5.372. PMID: 1609381; PMCID: PMC463754. 10: Fromenty B, Fisch C, Labbe G, Degott C, Deschamps D, Berson A, Letteron P, Pessayre D. Amiodarone inhibits the mitochondrial beta-oxidation of fatty acids and produces microvesicular steatosis of the liver in mice. J Pharmacol Exp Ther. 1990 Dec;255(3):1371-6. PMID: 2124623.

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