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MedKoo Cat#: 591799 | Name: RM175

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RM175 causes metastasis reduction.

Chemical Structure

RM175
RM175
CAS#336876-16-5

Theoretical Analysis

MedKoo Cat#: 591799

Name: RM175

CAS#: 336876-16-5

Chemical Formula: C16H24ClF6N2PRu+

Exact Mass: 526.0308

Molecular Weight: 525.87

Elemental Analysis: C, 36.54; H, 4.60; Cl, 6.74; F, 21.68; N, 5.33; P, 5.89; Ru, 19.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
RM175; RM 175; RM-175
IUPAC/Chemical Name
Ruthenium(1+), [(1,2,3,4,5,6-η)-1,1'-biphenyl]chloro(1,2-ethanediamine-κN,κN')-, hexafluorophosphate(1-) (9CI)
InChi Key
QPCBNYGRNHUDRE-UHFFFAOYSA-M
InChi Code
InChI=1S/C7H8.C6H6.C2H6N2.CH4.ClH.F6P.Ru/c1-7-5-3-2-4-6-7;1-2-4-6-5-3-1;3-1-2-4;;;1-7(2,3,4,5)6;/h2-6H,1H3;1-6H;3-4H,1-2H2;1H4;1H;;/q;;-2;;;+1;+3/p-1
SMILES Code
Cc1ccccc1.Cl[Ru]2NCCN2.F[P+](F)(F)(F)(F)F.c3ccccc3.C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 525.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Artner C, Holtkamp HU, Hartinger CG, Meier-Menches SM. Characterizing activation mechanisms and binding preferences of ruthenium metallo-prodrugs by a competitive binding assay. J Inorg Biochem. 2017 Dec;177:322-327. doi: 10.1016/j.jinorgbio.2017.07.010. Epub 2017 Jul 16. PubMed PMID: 28739166. 2: Bergamo A, Gaiddon C, Schellens JH, Beijnen JH, Sava G. Approaching tumour therapy beyond platinum drugs: status of the art and perspectives of ruthenium drug candidates. J Inorg Biochem. 2012 Jan;106(1):90-9. doi: 10.1016/j.jinorgbio.2011.09.030. Epub 2011 Sep 29. Review. PubMed PMID: 22112845. 3: Bergamo A, Masi A, Peacock AF, Habtemariam A, Sadler PJ, Sava G. In vivo tumour and metastasis reduction and in vitro effects on invasion assays of the ruthenium RM175 and osmium AFAP51 organometallics in the mammary cancer model. J Inorg Biochem. 2010 Jan;104(1):79-86. doi: 10.1016/j.jinorgbio.2009.10.005. Epub 2009 Oct 14. PubMed PMID: 19906432. 4: Bratsos I, Jedner S, Bergamo A, Sava G, Gianferrara T, Zangrando E, Alessio E. Half-sandwich Ru II[9]aneS3 complexes structurally similar to antitumor-active organometallic piano-stool compounds: preparation, structural characterization and in vitro cytotoxic activity. J Inorg Biochem. 2008 May-Jun;102(5-6):1120-33. doi: 10.1016/j.jinorgbio.2008.01.005. Epub 2008 Jan 9. PubMed PMID: 18279961. 5: Guichard SM, Else R, Reid E, Zeitlin B, Aird R, Muir M, Dodds M, Fiebig H, Sadler PJ, Jodrell DI. Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds. Biochem Pharmacol. 2006 Feb 14;71(4):408-15. Epub 2005 Dec 19. PubMed PMID: 16360645. 6: Hayward RL, Schornagel QC, Tente R, Macpherson JS, Aird RE, Guichard S, Habtemariam A, Sadler P, Jodrell DI. Investigation of the role of Bax, p21/Waf1 and p53 as determinants of cellular responses in HCT116 colorectal cancer cells exposed to the novel cytotoxic ruthenium(II) organometallic agent, RM175. Cancer Chemother Pharmacol. 2005 Jun;55(6):577-83. Epub 2005 Feb 22. PubMed PMID: 15726367. 7: Yan CJ, Liang GH, Chen F, Li X, Tang SZ, Yi CD, Tian S, Lu JF, Gu MH. [Mapping quantitative trait loci associated with rice grain shape based on an indica/japonica backcross population]. Yi Chuan Xue Bao. 2003 Aug;30(8):711-6. Chinese. PubMed PMID: 14682238. 8: Aird RE, Cummings J, Ritchie AA, Muir M, Morris RE, Chen H, Sadler PJ, Jodrell DI. In vitro and in vivo activity and cross resistance profiles of novel ruthenium (II) organometallic arene complexes in human ovarian cancer. Br J Cancer. 2002 May 20;86(10):1652-7. PubMed PMID: 12085218; PubMed Central PMCID: PMC2746580.

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