Mca-APK(Dnp)-OH | CAS#305336-82-7 | ACE2 quenched fluorogenic substrate

MedKoo Cat#: 463597 | Name: Mca-APK(Dnp)-OH

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mca-APK(Dnp)-OH is a specific ACE2 quenched fluorogenic substrate, being used for testing ACE2 activity.

Chemical Structure

Mca-APK(Dnp)-OH

CAS#305336-82-7

Theoretical Analysis

MedKoo Cat#: 463597

Name: Mca-APK(Dnp)-OH

CAS#: 305336-82-7

Chemical Formula: C32H36N6O12

Exact Mass: 696.2391

Molecular Weight: 696.67

Elemental Analysis: C, 55.17; H, 5.21; N, 12.06; O, 27.56

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
10mg	USD 650.00	2 Weeks

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Synonym

Mca-APK(Dnp)-OH; McaAPK(Dnp)-OH; Mca APK(Dnp)-OH; Mca-APK(Dnp)OH; Mca-APK(Dnp) OH; McaAPK(Dnp)OH; Mca APK(Dnp) OH; Mca-Ala-Pro-Lys(Dnp)-OH;

IUPAC/Chemical Name

N6-(2,4-dinitrophenyl)-N2-(2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl)-L-alanyl-L-prolyl-L-lysine

InChi Key

INOZJECNSBDPGT-WDNCENIBSA-N

InChi Code

InChI=1S/C32H36N6O12/c1-18(34-28(39)14-19-15-29(40)50-27-17-21(49-2)9-10-22(19)27)31(42)36-13-5-7-25(36)30(41)35-24(32(43)44)6-3-4-12-33-23-11-8-20(37(45)46)16-26(23)38(47)48/h8-11,15-18,24-25,33H,3-7,12-14H2,1-2H3,(H,34,39)(H,35,41)(H,43,44)/t18-,24-,25-/m0/s1

SMILES Code

O=C(OC1=C2C=CC(OC)=C1)C=C2CC(N[C@@H](C)C(N3CCC[C@H]3C(N[C@H](C(O)=O)CCCCNC4=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C4)=O)=O)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Product Data

Product Data

Instruction

View handling instruction

Biological target:

Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity.

In vitro activity:

TBD

In vivo activity:

TBD

	Solvent	mg/mL	mM
Solubility
	DMSO	50.0	71.77

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 696.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:

TBD

In vitro protocol:

TBD

In vivo protocol:

TBD

1: Pedersen KB, Chhabra KH, Nguyen VK, Xia H, Lazartigues E. The transcription factor HNF1α induces expression of angiotensin-converting enzyme 2 (ACE2) in pancreatic islets from evolutionarily conserved promoter motifs. Biochim Biophys Acta. 2013 Nov;1829(11):1225-35. doi: 10.1016/j.bbagrm.2013.09.007. Epub 2013 Oct 5. PMID: 24100303; PMCID: PMC3838857.