Desethylamiodarone | CAS#83409-32-9 (free base) | amiodarone metabolite

MedKoo Cat#: 598495 | Name: Desethylamiodarone

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desethylamiodarone is a metabolite of amiodarone.

Chemical Structure

Desethylamiodarone

CAS#83409-32-9 (free base)

Theoretical Analysis

MedKoo Cat#: 598495

Name: Desethylamiodarone

CAS#: 83409-32-9 (free base)

Chemical Formula: C23H25I2NO3

Exact Mass: 616.9924

Molecular Weight: 617.26

Elemental Analysis: C, 44.75; H, 4.08; I, 41.12; N, 2.27; O, 7.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

83409-32-9 (free base) 96027-74-6 (HCl)

Synonym

Desethylamiodarone; Deethylamiodarone; LB 33020; LB-33020; LB33020; N-Deethylamiodarone; DAMI; N-Monodesethylamiodarone;

IUPAC/Chemical Name

(2-butylbenzofuran-3-yl)(4-(2-(ethylamino)ethoxy)-3,5-diiodophenyl)methanone

InChi Key

VXOKDLACQICQFA-UHFFFAOYSA-N

InChi Code

InChI=1S/C23H25I2NO3/c1-3-5-9-20-21(16-8-6-7-10-19(16)29-20)22(27)15-13-17(24)23(18(25)14-15)28-12-11-26-4-2/h6-8,10,13-14,26H,3-5,9,11-12H2,1-2H3

SMILES Code

O=C(C1=C(CCCC)OC2=CC=CC=C12)C3=CC(I)=C(OCCNCC)C(I)=C3

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 617.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Preparation and determination of desethylamiodarone in dog lung by HPLC-MS. Pharmazie. 2011 Nov;66(11):822-5. PubMed PMID: 22204125. 5: Lu JT, Cai Y, Chen F, Jia WW, Hu ZY, Zhao YS. A Physiologically Based Pharmacokinetic Model of Amiodarone and its Metabolite Desethylamiodarone in Rats: Pooled Analysis of Published Data. Eur J Drug Metab Pharmacokinet. 2016 Dec;41(6):689-703. PubMed PMID: 26254911. 6: Roth FC, Mulder JE, Brien JF, Takahashi T, Massey TE. Cytotoxic interaction between amiodarone and desethylamiodarone in human peripheral lung epithelial cells. Chem Biol Interact. 2013 Aug 25;204(3):135-9. doi: 10.1016/j.cbi.2013.05.006. Epub 2013 May 23. PubMed PMID: 23707191. 7: Rodrigues M, Alves G, Rocha M, Queiroz J, Falcão A. First liquid chromatographic method for the simultaneous determination of amiodarone and desethylamiodarone in human plasma using microextraction by packed sorbent (MEPS) as sample preparation procedure. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jan 15;913-914:90-7. doi: 10.1016/j.jchromb.2012.11.028. Epub 2012 Dec 7. PubMed PMID: 23286980. 8: Kuhn J, Götting C, Kleesiek K. Simultaneous measurement of amiodarone and desethylamiodarone in human plasma and serum by stable isotope dilution liquid chromatography-tandem mass spectrometry assay. J Pharm Biomed Anal. 2010 Jan 5;51(1):210-6. doi: 10.1016/j.jpba.2009.08.004. Epub 2009 Aug 12. PubMed PMID: 19720490. 9: Stäubli M, Troendle A, Schmid B, Balmer P, Kohler B, Studer H, Bircher J. Pharmacokinetics of amiodarone, desethylamiodarone and other iodine-containing amiodarone metabolites. Eur J Clin Pharmacol. 1985;29(4):417-23. PubMed PMID: 4092724. 10: Gross SA, Bandyopadhyay S, Klaunig JE, Somani P. Amiodarone and desethylamiodarone toxicity in isolated hepatocytes in culture. Proc Soc Exp Biol Med. 1989 Feb;190(2):163-9. PubMed PMID: 2536944. 11: Giardina EG, Schneider M, Barr ML. Myocardial amiodarone and desethylamiodarone concentrations in patients undergoing cardiac transplantation. J Am Coll Cardiol. 1990 Oct;16(4):943-7. PubMed PMID: 2212375. 12: Somani P, Bandyopadhyay S, Klaunig JE, Gross SA. Amiodarone- and desethylamiodarone-induced myelinoid inclusion bodies and toxicity in cultured rat hepatocytes. Hepatology. 1990 Jan;11(1):81-92. PubMed PMID: 2153095. 13: Grossmann M, Dobrev D, Himmel HM, Kirch W. Local venous response to N-desethylamiodarone in humans. Clin Pharmacol Ther. 2000 Jan;67(1):22-31. PubMed PMID: 10668850. 14: Plomp TA, Wiersinga WM, van Rossum JM, Maes RA. Pharmacokinetics and body distribution of amiodarone and desethylamiodarone in rats after intravenous administration. In Vivo. 1989 Jan-Feb;3(1):33-47. PubMed PMID: 2519831. 15: Talajic M, DeRoode MR, Nattel S. Comparative electrophysiologic effects of intravenous amiodarone and desethylamiodarone in dogs: evidence for clinically relevant activity of the metabolite. Circulation. 1987 Jan;75(1):265-71. PubMed PMID: 3791608. 16: Beddows SA, Page SR, Taylor AH, McNerney R, Whitley GS, Johnstone AP, Nussey SS. Cytotoxic effects of amiodarone and desethylamiodarone on human thyrocytes. Biochem Pharmacol. 1989 Dec 15;38(24):4397-403. PubMed PMID: 2604742. 17: Barbieri E, Conti F, Zampieri P, Trevi GP, Zardini P, d'Aranno V, Latini R. Amiodarone and desethylamiodarone distribution in the atrium and adipose tissue of patients undergoing short- and long-term treatment with amiodarone. J Am Coll Cardiol. 1986 Jul;8(1):210-3. PubMed PMID: 3711518. 18: Vig PJ, Desaiah D. Modulation of protein kinase C activity by amiodarone and desethylamiodarone. Neurotoxicology. 1991 Fall;12(3):595-601. PubMed PMID: 1745442. 19: Nattel S, Davies M, Quantz M. The antiarrhythmic efficacy of amiodarone and desethylamiodarone, alone and in combination, in dogs with acute myocardial infarction. Circulation. 1988 Jan;77(1):200-8. PubMed PMID: 2446801. 20: Plomp TA, Wiersinga WM, Van Rossum JM, Maes RA. Pharmacokinetics and body distribution of amiodarone and desethylamiodarone in rats after oral administration. In Vivo. 1987 Sep-Oct;1(5):265-79. PubMed PMID: 2979794.