MedKoo Cat#: 413530 | Name: Penciclovir sodium

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Penciclovir sodium is an Antiviral (Treatment of Herpes Virus Infections)

Chemical Structure

Penciclovir sodium
Penciclovir sodium
CAS#97845-62-0 (Na)

Theoretical Analysis

MedKoo Cat#: 413530

Name: Penciclovir sodium

CAS#: 97845-62-0 (Na)

Chemical Formula: C10H14N5NaO3

Exact Mass:

Molecular Weight: 275.24

Elemental Analysis: C, 43.64; H, 5.13; N, 25.44; Na, 8.35; O, 17.44

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Synonym
Penciclovir sodium; BRL39123-D; BRL-39123-D; BRL 39123-D
IUPAC/Chemical Name
2-Amino-1,9-dihydro-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one monosodium salt
InChi Key
BRPTUOYNOCSFRJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C10H14N5O3.Na/c11-10-13-8-7(9(18)14-10)12-5-15(8)2-1-6(3-16)4-17;/h5-6,16H,1-4H2,(H3,11,13,14,18);/q-1;+1
SMILES Code
O=C1NC(N)=NC2=C1N=CN2CCC(C[O-])CO.[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
To be determined 0.0 0.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 275.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Meira RZC, Biscaia IFB, Nogueira C, Murakami FS, Bernardi LS, Oliveira PR. Solid-State Characterization and Compatibility Studies of Penciclovir, Lysine Hydrochloride, and Pharmaceutical Excipients. Materials (Basel). 2019 Sep 27;12(19):3154. doi: 10.3390/ma12193154. PMID: 31569620; PMCID: PMC6803830. 2: Vere Hodge RA, Sutton D, Boyd MR, Harnden MR, Jarvest RL. Selection of an oral prodrug (BRL 42810; famciclovir) for the antiherpesvirus agent BRL 39123 [9-(4-hydroxy-3-hydroxymethylbut-l-yl)guanine; penciclovir]. Antimicrob Agents Chemother. 1989 Oct;33(10):1765-73. doi: 10.1128/aac.33.10.1765. PMID: 2589844; PMCID: PMC172752. 3: Wang P, Li M, Zhao L, Yang Y, Ding X. [Uniform and orthogonal designs on experimental design and optimization of micellar electrokinetic capillary chromatographic method for the simultaneous analysis of three nucleoside antivirus drugs in disinfectant and anti/bacteriostatic products]. Se Pu. 2018 Sep 8;36(9):931-937. Chinese. doi: 10.3724/SP.J.1123.2018.04003. PMID: 30251523. 4: Mathialagan S, Costales C, Tylaska L, Kimoto E, Vildhede A, Johnson J, Johnson N, Sarashina T, Hashizume K, Isringhausen CD, Vermeer LMM, Wolff AR, Rodrigues AD. In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica. 2018 Oct;48(10):1037-1049. doi: 10.1080/00498254.2017.1384595. Epub 2017 Oct 13. PMID: 28945155. 5: Schenkel F, Rudaz S, Daali Y, Oestreicher MK, Veuthey JL, Dayer P. Development and validation of a new reversed-phase ion pairing liquid chromatographic method with fluorescence detection for penciclovir analysis in plasma and aqueous humor. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Nov 5;826(1-2):1-7. doi: 10.1016/j.jchromb.2005.07.022. Epub 2005 Sep 1. PMID: 16140045. 6: Kim JE, Hwang MH, Lee HW, Lee SW, Lee J, Ahn BC. Combined RNA interference of adenine nucleotide translocase-2 and ganciclovir therapy in hepatocellular carcinoma. Nucl Med Biol. 2013 Nov;40(8):987-93. doi: 10.1016/j.nucmedbio.2013.08.004. Epub 2013 Sep 17. PMID: 24054501. 7: Uwai Y, Ozeki Y, Isaka T, Honjo H, Iwamoto K. Inhibitory effect of caffeic acid on human organic anion transporters hOAT1 and hOAT3: a novel candidate for food-drug interaction. Drug Metab Pharmacokinet. 2011;26(5):486-93. doi: 10.2133/dmpk.dmpk-11-rg-020. Epub 2011 Jun 21. PMID: 21697612. 8: Cheng Y, Vapurcuyan A, Shahidullah M, Aleksunes LM, Pelis RM. Expression of organic anion transporter 2 in the human kidney and its potential role in the tubular secretion of guanine-containing antiviral drugs. Drug Metab Dispos. 2012 Mar;40(3):617-24. doi: 10.1124/dmd.111.042036. Epub 2011 Dec 21. PMID: 22190696.