MedKoo Cat#: 318670 | Name: Ritodrine HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ritodrine HCl is a β2-adrenoceptor agonist that acts as an adrenergic receptor stimulant. It gives priority to act on the adrenergic receptors on the uterine smooth muscle through membrane-mediated effects of uterine smooth muscle cells, and uterine smooth muscle cells β2-AR (β2-adrenoceptor).

Chemical Structure

Ritodrine HCl
Ritodrine HCl
CAS#23239-51-2 (HCl)

Theoretical Analysis

MedKoo Cat#: 318670

Name: Ritodrine HCl

CAS#: 23239-51-2 (HCl)

Chemical Formula: C17H22ClNO3

Exact Mass:

Molecular Weight: 323.81

Elemental Analysis: C, 63.06; H, 6.85; Cl, 10.95; N, 4.33; O, 14.82

Price and Availability

Size Price Availability Quantity
100mg USD 150.00
200mg USD 250.00
500mg USD 450.00
1g USD 650.00
2g USD 1,150.00
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Related CAS #
26652-09-5 (free base) 23239-51-2 (HCl)
Synonym
Ritodrine Hydrochloride; Ritodrine (hydrochloride); (+-)-Ritodrine hydrochloride; ST51015115; Pre-Par; Utopar;
IUPAC/Chemical Name
4-[2-[[(1S,2R)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]phenol;hydrochloride
InChi Key
IDLSITKDRVDKRV-JSUROZADSA-N
InChi Code
InChI=1S/C17H21NO3.ClH/c1-12(17(21)14-4-8-16(20)9-5-14)18-11-10-13-2-6-15(19)7-3-13;/h2-9,12,17-21H,10-11H2,1H3;1H/t12-,17-;/m1./s1
SMILES Code
CC(C(C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)O.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO, ethanol, and water
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO, ethanol, and water
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Biological target:
Ritodrine HCl is a salt.
In vitro activity:
Ritodrine may promote the proliferation of fetal hepatocytes through the stimulation of β2-adrenergic receptors, followed by induction of deoxyribonucleic acid synthesis. Ritodrine was added to serum- and hormone-free primary cultures of fetal, neonatal, or adult rat hepatocytes to test its direct effect on fetal cell proliferation. Reference: Am J Obstet Gynecol. 1993 Feb;168(2):693-7. https://pubmed.ncbi.nlm.nih.gov/8438951/
In vivo activity:
Ritodrine hydrochloride infusion in pregnant women increased the fetal movement and decreased the no-fetal movement period at 32-35 weeks. Reference: J Obstet Gynaecol Res. 2023 Feb;49(2):606-613. https://pubmed.ncbi.nlm.nih.gov/36443932/
Solvent mg/mL mM
Solubility
DMSO 65.0 200.73
Ethanol 65.0 200.73
Water 65.0 200.73
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 323.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Hacivelioglu S, Cirpan T, Cosan Terek M, Kanit L, Kazandi M, Oztekin K. In vitro effects of ritodrine, magnesium sulfate and their combination on spontaneous contractions of myometrial strips of pregnant rat uteri. Clin Exp Obstet Gynecol. 2007;34(4):223-7. PMID: 18225683. 2. Ando H, Kasugai M, Ishihara Y, Kurauchi O, Suganuma N, Mizutani S, Tomoda Y. Enhanced proliferation of fetal rat hepatocytes in primary culture induced by ritodrine. Am J Obstet Gynecol. 1993 Feb;168(2):693-7. doi: 10.1016/0002-9378(93)90518-n. PMID: 8438951. 3. Yonaga Y, Ryo E, Yatsuki K, Kamata H, Ito A. Effect of ritodrine hydrochloride infusion on fetal movement with the use of a fetal movement acceleration measurement recorder (FMAM recorder). J Obstet Gynaecol Res. 2023 Feb;49(2):606-613. doi: 10.1111/jog.15512. Epub 2022 Nov 28. PMID: 36443932. 4. Murata T, Kyozuka H, Yasuda S, Fukuda T, Yamaguchi A, Maeda H, Sato A, Ogata Y, Shinoki K, Hosoya M, Yasumura S, Hashimoto K, Nishigori H, Fujimori K; Japan Environment, Children’s Study (JECS) Group. Association between maternal ritodrine hydrochloride administration during pregnancy and childhood wheezing up to three years of age: The Japan environment and children's study. Pediatr Allergy Immunol. 2021 Oct;32(7):1455-1463. doi: 10.1111/pai.13545. Epub 2021 Jun 29. PMID: 34013624.
In vitro protocol:
1. Hacivelioglu S, Cirpan T, Cosan Terek M, Kanit L, Kazandi M, Oztekin K. In vitro effects of ritodrine, magnesium sulfate and their combination on spontaneous contractions of myometrial strips of pregnant rat uteri. Clin Exp Obstet Gynecol. 2007;34(4):223-7. PMID: 18225683. 2. Ando H, Kasugai M, Ishihara Y, Kurauchi O, Suganuma N, Mizutani S, Tomoda Y. Enhanced proliferation of fetal rat hepatocytes in primary culture induced by ritodrine. Am J Obstet Gynecol. 1993 Feb;168(2):693-7. doi: 10.1016/0002-9378(93)90518-n. PMID: 8438951.
In vivo protocol:
1. Yonaga Y, Ryo E, Yatsuki K, Kamata H, Ito A. Effect of ritodrine hydrochloride infusion on fetal movement with the use of a fetal movement acceleration measurement recorder (FMAM recorder). J Obstet Gynaecol Res. 2023 Feb;49(2):606-613. doi: 10.1111/jog.15512. Epub 2022 Nov 28. PMID: 36443932. 2. Murata T, Kyozuka H, Yasuda S, Fukuda T, Yamaguchi A, Maeda H, Sato A, Ogata Y, Shinoki K, Hosoya M, Yasumura S, Hashimoto K, Nishigori H, Fujimori K; Japan Environment, Children’s Study (JECS) Group. Association between maternal ritodrine hydrochloride administration during pregnancy and childhood wheezing up to three years of age: The Japan environment and children's study. Pediatr Allergy Immunol. 2021 Oct;32(7):1455-1463. doi: 10.1111/pai.13545. Epub 2021 Jun 29. PMID: 34013624.
1: Kareli D, Pouliliou S, Liberis A, Nikas I, Psillaki A, Kontomanolis E, Nikolettos N, Galazios G, Lialiaris T. Genotoxic effect of tocolytic drug ritodrine in combination with smoking during pregnancy. J Matern Fetal Neonatal Med. 2016 Mar 18:1-10. [Epub ahead of print] PubMed PMID: 26742485. 2: Kinoshita H, Katoh Y, Yoshino H, Sumie Y, Tanaka M, Fujiwara Y. Acute hypokalemia induced by ritodrine and rebound hyperkalemia in a parturient undergoing a cesarean section. J Clin Anesth. 2016 Feb;28:78-9. doi: 10.1016/j.jclinane.2015.05.019. Epub 2015 Jun 29. PubMed PMID: 26138627. 3: Hui Y, Liu MC. Sulfation of ritodrine by the human cytosolic sulfotransferases (SULTs): Effects of SULT1A3 genetic polymorphism. Eur J Pharmacol. 2015 Aug 15;761:125-9. doi: 10.1016/j.ejphar.2015.04.039. Epub 2015 May 2. PubMed PMID: 25941087; PubMed Central PMCID: PMC4532560. 4: Baykal BÖ, Avcıoğlu SN. Comparison of effects of nifedipine and ritodrine on maternal and fetal blood flow patterns in preterm labor. J Turk Ger Gynecol Assoc. 2015 Jun 1;16(2):80-5. doi: 10.5152/jtgga.2015.15156. eCollection 2015. PubMed PMID: 26097389; PubMed Central PMCID: PMC4456978. 5: Onishi H, Sakata O, Yumoto K. In vitro and in vivo evaluations of buccal tablet formulations of ritodrine hydrochloride. Biol Pharm Bull. 2015;38(6):919-25. doi: 10.1248/bpb.b14-00833. PubMed PMID: 26027834. 6: Boğa Pekmezekmek A, Binokay US, Seçilmiş MA, Kumcu E, Şimşek E, Akillioğlu K, Sertdemir Y, Özaykan B. Evaluating the Teratogenicity of Ritodrine and Nifedipine using a Frog Embryo Teratogenesis assay (FETAX). Drug Chem Toxicol. 2015;38(3):254-65. doi: 10.3109/01480545.2014.947423. Epub 2014 Aug 26. PubMed PMID: 25156158. 7: Driul L, Londero AP, Adorati-Menegato A, Vogrig E, Bertozzi S, Fachechi G, Forzano L, Cacciaguerra G, Perin E, Miceli A, Marchesoni D. Therapy side-effects and predictive factors for preterm delivery in patients undergoing tocolysis with atosiban or ritodrine for threatened preterm labour. J Obstet Gynaecol. 2014 Nov;34(8):684-9. doi: 10.3109/01443615.2014.930094. Epub 2014 Jun 24. PubMed PMID: 24959721. 8: Onishi H, Yumoto K, Sakata O. Preparation and evaluation of ritodrine buccal tablets for rational therapeutic use. Int J Pharm. 2014 Jul 1;468(1-2):207-13. doi: 10.1016/j.ijpharm.2014.04.009. Epub 2014 Apr 5. PubMed PMID: 24709218. 9: Zhang L, Liu X, Li J. Ritodrine-induced agranulocytosis in pregnancy. J Obstet Gynaecol. 2014 Aug;34(6):533-4. doi: 10.3109/01443615.2014.914481. Epub 2014 May 15. PubMed PMID: 24830665. 10: Park JY, Lee NR, Lee KE, Park S, Kim YJ, Gwak HS. Effects of β2-adrenergic receptor gene polymorphisms on ritodrine therapy in pregnant women with preterm labor: prospective follow-up study. Int J Mol Sci. 2014 Jul 21;15(7):12885-94. doi: 10.3390/ijms150712885. PubMed PMID: 25050782; PubMed Central PMCID: PMC4139879. 11: Kim MJ, Hwang I, Bae JY, Seong WJ. The influence of ritodrine alone or in combination with nifedipine on maternal cardiovascular side effects and pregnancy outcomes. Clin Exp Obstet Gynecol. 2014;41(5):537-40. PubMed PMID: 25864255. 12: Chen SY, Fan SZ, Chen LK. Ultralow dose combined spinal-epidural anesthesia for cesarean section in ritodrine-related severe pulmonary hypertension. Taiwan J Obstet Gynecol. 2013 Dec;52(4):617. doi: 10.1016/j.tjog.2013.10.035. PubMed PMID: 24411060. 13: Sugiura Y, Nemoto E, Kadohira I, Kaseda S. Ritodrine for intractable uterine pain due to extrapelvic malignant tumor metastases: a case report. Clin J Pain. 2013 Nov;29(11):e22-5. doi: 10.1097/AJP.0b013e31828c4c13. PubMed PMID: 23567162. 14: Sakata O, Onishi H. In vivo absorption study of ritodrine hydrochloride in the buccal administration to rats. Drug Dev Ind Pharm. 2013 Sep;39(9):1414-20. doi: 10.3109/03639045.2012.704044. Epub 2012 Jul 10. PubMed PMID: 22779426. 15: Tsuchiya H, Sato J, Tsuda H, Fujiwara Y, Yamada T, Fujimura A, Koshimizu TA. Serum amyloid A upsurge precedes standard biomarkers of hepatotoxicity in ritodrine-injected mice. Toxicology. 2013 Mar 8;305:79-88. doi: 10.1016/j.tox.2013.01.012. Epub 2013 Jan 28. PubMed PMID: 23370008. 16: Ogawa M, Matsuda Y, Kobayashi A, Shimada E, Akizawa Y, Mitani M, Makino Y, Matsui H. Ritodrine Should Be Carefully Administered during Antenatal Glucocorticoid Therapy Even in Nondiabetic Pregnancies. ISRN Obstet Gynecol. 2013;2013:120735. doi: 10.1155/2013/120735. Epub 2013 Feb 28. PubMed PMID: 23533796; PubMed Central PMCID: PMC3603405. 17: Kimura M, Kato T, Nohara R. Pulmonary edema complicating ritodrine infusion in a patient with premature labor. Intern Med. 2013;52(1):155. Epub 2013 Jan 1. PubMed PMID: 23291694. 18: Tsuchiya H, Ushijima K, Fujiwara Y, Fujimura A, Koshimizu TA. Chronic ritodrine treatment induces refractoriness of glucose-lowering β2 adrenoceptor signal in female mice. Regul Toxicol Pharmacol. 2012 Apr;62(3):561-7. doi: 10.1016/j.yrtph.2011.11.011. Epub 2011 Dec 1. PubMed PMID: 22154823. 19: Yasuda R, Makino Y, Matsuda Y, Kawamichi Y, Matsui H. Agranulocytosis associated with intravenous ritodrine hydrochloride therapy: two case reports by different mechanisms. J Obstet Gynaecol Res. 2012 Mar;38(3):574-7. doi: 10.1111/j.1447-0756.2011.01756.x. Epub 2012 Feb 22. PubMed PMID: 22353036. 20: Nikolettos N, Triantafillidis I, Karachaliou V, Koutsougeras G, Vakalopoulos I. The effects of benzoylecgonine, oxytocin, ritodrine and atosiban on the contractility of myometrium. An experimental study. Clin Exp Obstet Gynecol. 2012;39(1):36-42. PubMed PMID: 22675953.