Cyclofenil diphenol | CAS# 5189-40-2 (diphenol) | non-steroidal oestrogen

MedKoo Cat#: 413416 | Name: Cyclofenil diphenol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cyclofenil diphenol is a weak non-steroidal oestrogen.

Chemical Structure

Cyclofenil diphenol

CAS#5189-40-2 (diphenol)

Theoretical Analysis

MedKoo Cat#: 413416

Name: Cyclofenil diphenol

CAS#: 5189-40-2 (diphenol)

Chemical Formula: C19H20O2

Exact Mass: 280.1463

Molecular Weight: 280.37

Elemental Analysis: C, 81.40; H, 7.19; O, 11.41

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

5189-40-2 (diphenol) 2624-43-3 (free base)

Synonym

Cyclofenil diphenol; F6060; F-6060; F 6060

IUPAC/Chemical Name

4-(Cyclohexylidene(4-hydroxyphenyl)methyl)phenol

InChi Key

POEZOFHZEJTFHF-UHFFFAOYSA-N

InChi Code

InChI=1S/C19H20O2/c20-17-10-6-15(7-11-17)19(14-4-2-1-3-5-14)16-8-12-18(21)13-9-16/h6-13,20-21H,1-5H2

SMILES Code

OC1=CC=C(/C(C2=CC=C(O)C=C2)=C3CCCCC\3)C=C1

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

	Solvent	mg/mL	mM
Solubility
	Soluble in DMSO	0.0	100.00

Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 280.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Mason RM, Lancaster CA. Effects of cyclofenil diphenol, an agent which disrupts Golgi structure, on proteoglycan synthesis in chondrocytes. Biochem J. 1992 Jan 15;281 ( Pt 2)(Pt 2):525-31. doi: 10.1042/bj2810525. PMID: 1736900; PMCID: PMC1130717. 2: Mason RM, Lineham JD, Phillipson MA, Black CM. Selective inhibition of proteoglycan and hyaluronate synthesis in chondrocyte cultures by cyclofenil diphenol, a non-steroidal weak oestrogen. Biochem J. 1984 Oct 15;223(2):401-12. doi: 10.1042/bj2230401. PMID: 6437390; PMCID: PMC1144312. 3: Lancaster CA, Fryer PR, Griffiths S, Mason RM. Ultrastructural changes accompany inhibition of proteoglycan synthesis in chondrocytes by Cyclofenil diphenol. J Cell Sci. 1989 Feb;92 ( Pt 2):271-80. PMID: 2777926. 4: Drecktrah D, de Figueiredo P, Mason RM, Brown WJ. Retrograde trafficking of both Golgi complex and TGN markers to the ER induced by nordihydroguaiaretic acid and cyclofenil diphenol. J Cell Sci. 1998 Apr;111 ( Pt 7):951-65. PMID: 9490639. 5: Giannina T, Steinetz B, Butler M, Chart J, Carney R. Some effects of bis(p-hydroxyphenyl)cyclohexylidenemethane (F 6060) and related compounds on reproduction and steroidogenesis in laboratory animals. Biol Reprod. 1969 Dec;1(4):397-406. doi: 10.1095/biolreprod1.4.397. PMID: 5406667.