Desmethylglycitein (DMG), a minor isoflavone predominantly found in fermented soy products, exhibits notable estrogenic and antioxidant activities. In vitro, DMG shows significant affinity for estrogen receptor β (ERβ), with a relative binding affinity of approximately 14% compared to estradiol, favoring ERβ over ERα, which suggests potential for tissue-selective estrogenic effects. DMG also demonstrates antioxidant properties, evidenced by its ability to inhibit lipid peroxidation in rat liver microsomes and scavenge DPPH radicals with an IC₅₀ of ~13 μM. Additionally, DMG has been shown to inhibit proliferation of MCF-7 breast cancer cells with an IC₅₀ around 30–40 μM, indicating weak antiproliferative activity that may be mediated through modulation of estrogen signaling pathways.
MedKoo Cat#: 128242
Name: Desmethylglycitein
CAS#: 17817-31-1
Chemical Formula: C15H10O5
Exact Mass: 270.0528
Molecular Weight: 270.24
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60
The following data is based on the product molecular weight 270.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
