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MedKoo Cat#: 464051 | Name: ADMA
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NG,NG-dimethyl-L-arginine (ADMA) is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet. ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.

Chemical Structure

ADMA
CAS#30315-93-6

Theoretical Analysis

MedKoo Cat#: 464051

Name: ADMA

CAS#: 30315-93-6

Chemical Formula: C8H18N4O2

Exact Mass: 202.1430

Molecular Weight: 202.26

Elemental Analysis: C, 47.51; H, 8.97; N, 27.70; O, 15.82

Price and Availability

Size Price Availability Quantity
100mg USD 450.00 2 Weeks
250mg USD 850.00 2 Weeks
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Related CAS #
30315-93-6 1313730-20-9 (deuterated forms)
Synonym
NG,NG-dimethyl-L-Arginine; Asymmetric dimethylarginine; Asymmetric-dimethylarginine;
IUPAC/Chemical Name
Nw,Nw-dimethyl-L-arginine
InChi Key
YDGMGEXADBMOMJ-LURJTMIESA-N
InChi Code
InChI=1S/C8H18N4O2/c1-12(2)8(10)11-5-3-4-6(9)7(13)14/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14)/t6-/m0/s1
SMILES Code
CN(C(NCCC[C@@H](C(O)=O)N)=N)C
Appearance
Purity
>95% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 202.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Zhao Y, Ma X, Zhou Y, Xie J, Liu X, Zhao Y. DDAH-1, via regulation of ADMA levels, protects against ischemia-induced blood-brain barrier leakage. Lab Invest. 2021 Feb 11. doi: 10.1038/s41374-021-00541-5. Epub ahead of print. PMID: 33574439. 2: Toyomasu K, Adachi H, Enomoto M, Fukami A, Nakamura S, Nohara Y, Morikawa N, Sakaue A, Hamamura H, Yamamoto M, Fukumoto Y. Impact of combined elevations of homocysteine and asymmetric dimethylarginine on all-cause death - The Tanushimaru Study. J Cardiol. 2021 Feb 4:S0914-5087(21)00026-5. doi: 10.1016/j.jjcc.2021.01.011. Epub ahead of print. PMID: 33551145. 3: Nikooei P, Hosseinzadeh-Attar MJ, Asghari S, Norouzy A, Yaseri M, Vasheghani- Farahani A. Effects of virgin coconut oil consumption on metabolic syndrome components and asymmetric dimethylarginine: A randomized controlled clinical trial. Nutr Metab Cardiovasc Dis. 2020 Nov 27:S0939-4753(20)30497-X. doi: 10.1016/j.numecd.2020.11.020. Epub ahead of print. PMID: 33549429. 4: Hsu CN, Hou CY, Chang-Chien GP, Lin S, Tain YL. Maternal Garlic Oil Supplementation Prevents High-Fat Diet-induced Hypertension in Adult Rat Offspring: Implications of H2S-generating Pathway in the Gut and Kidneys. Mol Nutr Food Res. 2021 Feb 5:e2001116. doi: 10.1002/mnfr.202001116. Epub ahead of print. PMID: 33547712. 5: Khan M, Singh I, Won J. Asymmetric dimethylarginine-induced oxidative damage leads to cerebrovascular dysfunction. Neural Regen Res. 2021 Sep;16(9):1793-1794. doi: 10.4103/1673-5374.306080. PMID: 33510080. 6: Zhang L, Zhang K, Dong W, Li R, Huang R, Zhang H, Shi W, Liu S, Li Z, Chen Y, Ye Z, Liang X, Yu X. Raised Plasma Levels of Asymmetric Dimethylarginine Are Associated with Pathological Type and Predict the Therapeutic Effect in Lupus Nephritis Patients Treated with Cyclophosphamide. Kidney Dis (Basel). 2020 Sep;6(5):355-363. doi: 10.1159/000509767. Epub 2020 Jul 28. PMID: 33490115; PMCID: PMC7745665. 7: Matjuda EN, Engwa GA, Anye SNC, Nkeh-Chungag BN, Goswami N. Cardiovascular Risk Factors and Their Relationship with Vascular Dysfunction in South African Children of African Ancestry. J Clin Med. 2021 Jan 19;10(2):354. doi: 10.3390/jcm10020354. PMID: 33477761; PMCID: PMC7832309. 8: Akil M. Effects of Caffeic Acid Phenethyl Ester and Oxidative Stress Caused by the Exhaustion Exercise on Endotelial Damage. Arch Ital Biol. 2020 Jun 30;158(2):37-44. doi: 10.12871/00039829202021. PMID: 33462797. 9: Jeffrey S, Samraj PI, Raj BS. The role of alpha-lipoic acid supplementation in the prevention of diabetes complications: A comprehensive review of clinical trials. Curr Diabetes Rev. 2021 Jan 18. doi: 10.2174/1573399817666210118145550. Epub ahead of print. PMID: 33461470. 10: Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR. Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem. 2020 Dec 18;295(51):17441-17459. doi: 10.1074/jbc.RA120.014884. PMID: 33453990; PMCID: PMC7762938. 11: Fan Y, Gao Q, Guan JX, Liu L, Hong M, Jun L, Wang L, Ding HF, Jiang LH, Hou BY, Li M, Song ZQ, Sun DQ, Yan CQ, Ma L. DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study. Neural Regen Res. 2021 Aug;16(8):1592-1597. doi: 10.4103/1673-5374.303037. PMID: 33433489. 12: Dai Y, Li TH, He X, Yan SB, Gao Y, Chen Y. The Effect and Mechanism of Asymmetric Dimethylarginine Regulating Trophoblastic Autophagy on Fetal Growth Restriction. Reprod Sci. 2021 Jan 11. doi: 10.1007/s43032-020-00442-w. Epub ahead of print. PMID: 33428125. 13: Molek P, Zmudzki P, Wlodarczyk A, Nessler J, Zalewski J. The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance. Sci Rep. 2021 Jan 8;11(1):83. doi: 10.1038/s41598-020-80230-3. PMID: 33420142; PMCID: PMC7794337. 14: Naserifar M, Ataei M, Behzadian N, Mohammadpour AH, Dastani M, Shamsara J, Elyasi S, Sahebkar A, Hosseinjani H. Corrigendum to "Evaluation of the Correlation between Serum Concentrations of Asymmetric Dimethylarginine and Corrected TIMI Frame Count in Patients with Slow Coronary Flow". Int J Vasc Med. 2020 Dec 11;2020:9796012. doi: 10.1155/2020/9796012. Erratum for: Int J Vasc Med. 2020 Sep 19;2020:4592190. PMID: 33414965; PMCID: PMC7752283. 15: Mangoni AA, Tommasi S, Sotgia S, Zinellu A, Paliogiannis P, Piga M, Cauli A, Pintus G, Carru C, Erre GL. Asymmetric dimethylarginine: a key player in the pathophysiology of endothelial dysfunction, vascular inflammation and atherosclerosis in rheumatoid arthritis? Curr Pharm Des. 2021 Jan 6. doi: 10.2174/1381612827666210106144247. Epub ahead of print. PMID: 33413061. 16: Hsu CN, Tain YL. Developmental Origins of Kidney Disease: Why Oxidative Stress Matters? Antioxidants (Basel). 2020 Dec 30;10(1):33. doi: 10.3390/antiox10010033. PMID: 33396856; PMCID: PMC7823649. 17: van Wijk XMR, Yun C, Lynch KL. Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality. J Appl Lab Med. 2020 Dec 31:jfaa156. doi: 10.1093/jalm/jfaa156. Epub ahead of print. PMID: 33382901. 18: Ertelt A, Stumpff F, Merle R, Kuban S, Bollinger L, Liertz S, Gehlen H. Asymmetric dimethylarginine-A potential cardiac biomarker in horses. J Vet Cardiol. 2021 Feb;33:43-51. doi: 10.1016/j.jvc.2020.11.002. Epub 2020 Nov 24. PMID: 33360109. 19: Bijkerk R, Kallenberg MH, Zijlstra LE, van den Berg BM, de Bresser J, Hammer S, Bron EE, Achterberg H, van Buchem MA, Berkhout-Byrne NC, Bos WJW, van Heemst D, Rabelink TJ, van Zonneveld AJ, van Buren M, Mooijaart S. Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end stage renal disease. Nephrol Dial Transplant. 2020 Dec 23:gfaa370. doi: 10.1093/ndt/gfaa370. Epub ahead of print. PMID: 33355649. 20: Brix B, Apich G, Ure C, Roessler A, Goswami N. Physical therapy affects endothelial function in lymphedema patients. Lymphology. 2020;53(3):109-117. PMID: 33350285.