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MedKoo Cat#: 463921 | Name: ADMA-d6
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet. ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease.

Chemical Structure

ADMA-d6
CAS#1313730-20-9 (deuterated forms)

Theoretical Analysis

MedKoo Cat#: 463921

Name: ADMA-d6

CAS#: 1313730-20-9 (deuterated forms)

Chemical Formula: C8H14D6Cl2N4O2

Exact Mass: 280.1340

Molecular Weight: 281.21

Elemental Analysis: C, 34.17; H, 9.32; Cl, 25.21; N, 19.92; O, 11.38

Price and Availability

Size Price Availability Quantity
1mg USD 350.00 2 Weeks
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Related CAS #
30315-93-6 1313730-20-9 (deuterated forms)
Synonym
ADMA-d6 hydrochloride; ADMA d6 hydrochloride; Asymmetric-dimethylarginine-d6 hydrochloride; Asymmetric dimethylarginine d6 hydrochloride;
IUPAC/Chemical Name
Nw,Nw-bis(methyl-d3)-L-arginine dihydrochloride
InChi Key
SYLNVYJOPZWPJI-WTPXGJEESA-N
InChi Code
InChI=1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14;;/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14);2*1H/t6-;;/m0../s1/i1D3,2D3;;
SMILES Code
[2H]C([2H])(N(C(NCCC[C@@H](C(O)=O)N)=N)C([2H])([2H])[2H])[2H].Cl.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 281.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Khan M, Singh I, Won J. Asymmetric dimethylarginine-induced oxidative damage leads to cerebrovascular dysfunction. Neural Regen Res. 2021 Sep;16(9):1793-1794. doi: 10.4103/1673-5374.306080. PMID: 33510080. 2: Zhang L, Zhang K, Dong W, Li R, Huang R, Zhang H, Shi W, Liu S, Li Z, Chen Y, Ye Z, Liang X, Yu X. Raised Plasma Levels of Asymmetric Dimethylarginine Are Associated with Pathological Type and Predict the Therapeutic Effect in Lupus Nephritis Patients Treated with Cyclophosphamide. Kidney Dis (Basel). 2020 Sep;6(5):355-363. doi: 10.1159/000509767. Epub 2020 Jul 28. PMID: 33490115; PMCID: PMC7745665. 3: Matjuda EN, Engwa GA, Anye SNC, Nkeh-Chungag BN, Goswami N. Cardiovascular Risk Factors and Their Relationship with Vascular Dysfunction in South African Children of African Ancestry. J Clin Med. 2021 Jan 19;10(2):354. doi: 10.3390/jcm10020354. PMID: 33477761; PMCID: PMC7832309. 4: Akil M. Effects of Caffeic Acid Phenethyl Ester and Oxidative Stress Caused by the Exhaustion Exercise on Endotelial Damage. Arch Ital Biol. 2020 Jun 30;158(2):37-44. doi: 10.12871/00039829202021. PMID: 33462797. 5: Jeffrey S, Samraj PI, Raj BS. The role of alpha-lipoic acid supplementation in the prevention of diabetes complications: A comprehensive review of clinical trials. Curr Diabetes Rev. 2021 Jan 18. doi: 10.2174/1573399817666210118145550. Epub ahead of print. PMID: 33461470. 6: Kunz HE, Dorschner JM, Berent TE, Meyer T, Wang X, Jatoi A, Kumar R, Lanza IR. Methylarginine metabolites are associated with attenuated muscle protein synthesis in cancer-associated muscle wasting. J Biol Chem. 2020 Dec 18;295(51):17441-17459. doi: 10.1074/jbc.RA120.014884. PMID: 33453990; PMCID: PMC7762938. 7: Fan Y, Gao Q, Guan JX, Liu L, Hong M, Jun L, Wang L, Ding HF, Jiang LH, Hou BY, Li M, Song ZQ, Sun DQ, Yan CQ, Ma L. DDAH2 (-449 G/C) G allele is positively associated with leukoaraiosis in northeastern China: a double-blind, intergroup comparison, case-control study. Neural Regen Res. 2021 Aug;16(8):1592-1597. doi: 10.4103/1673-5374.303037. PMID: 33433489. 8: Dai Y, Li TH, He X, Yan SB, Gao Y, Chen Y. The Effect and Mechanism of Asymmetric Dimethylarginine Regulating Trophoblastic Autophagy on Fetal Growth Restriction. Reprod Sci. 2021 Jan 11. doi: 10.1007/s43032-020-00442-w. Epub ahead of print. PMID: 33428125. 9: Molek P, Zmudzki P, Wlodarczyk A, Nessler J, Zalewski J. The shifted balance of arginine metabolites in acute myocardial infarction patients and its clinical relevance. Sci Rep. 2021 Jan 8;11(1):83. doi: 10.1038/s41598-020-80230-3. PMID: 33420142; PMCID: PMC7794337. 10: Naserifar M, Ataei M, Behzadian N, Mohammadpour AH, Dastani M, Shamsara J, Elyasi S, Sahebkar A, Hosseinjani H. Corrigendum to "Evaluation of the Correlation between Serum Concentrations of Asymmetric Dimethylarginine and Corrected TIMI Frame Count in Patients with Slow Coronary Flow". Int J Vasc Med. 2020 Dec 11;2020:9796012. doi: 10.1155/2020/9796012. Erratum for: Int J Vasc Med. 2020 Sep 19;2020:4592190. PMID: 33414965; PMCID: PMC7752283. 11: Mangoni AA, Tommasi S, Sotgia S, Zinellu A, Paliogiannis P, Piga M, Cauli A, Pintus G, Carru C, Erre GL. Asymmetric dimethylarginine: a key player in the pathophysiology of endothelial dysfunction, vascular inflammation and atherosclerosis in rheumatoid arthritis? Curr Pharm Des. 2021 Jan 6. doi: 10.2174/1381612827666210106144247. Epub ahead of print. PMID: 33413061. 12: Hsu CN, Tain YL. Developmental Origins of Kidney Disease: Why Oxidative Stress Matters? Antioxidants (Basel). 2020 Dec 30;10(1):33. doi: 10.3390/antiox10010033. PMID: 33396856; PMCID: PMC7823649. 13: van Wijk XMR, Yun C, Lynch KL. Evaluation of Biomarkers in Sepsis: High Dimethylarginine (ADMA and SDMA) Concentrations Are Associated with Mortality. J Appl Lab Med. 2020 Dec 31:jfaa156. doi: 10.1093/jalm/jfaa156. Epub ahead of print. PMID: 33382901. 14: Ertelt A, Stumpff F, Merle R, Kuban S, Bollinger L, Liertz S, Gehlen H. Asymmetric dimethylarginine-A potential cardiac biomarker in horses. J Vet Cardiol. 2020 Nov 24;33:43-51. doi: 10.1016/j.jvc.2020.11.002. Epub ahead of print. PMID: 33360109. 15: Bijkerk R, Kallenberg MH, Zijlstra LE, van den Berg BM, de Bresser J, Hammer S, Bron EE, Achterberg H, van Buchem MA, Berkhout-Byrne NC, Bos WJW, van Heemst D, Rabelink TJ, van Zonneveld AJ, van Buren M, Mooijaart S. Circulating angiopoietin-2 and angiogenic microRNAs associate with cerebral small vessel disease and cognitive decline in older patients reaching end stage renal disease. Nephrol Dial Transplant. 2020 Dec 23:gfaa370. doi: 10.1093/ndt/gfaa370. Epub ahead of print. PMID: 33355649. 16: Brix B, Apich G, Ure C, Roessler A, Goswami N. Physical therapy affects endothelial function in lymphedema patients. Lymphology. 2020;53(3):109-117. PMID: 33350285. 17: Wei M, Tan C, Tang Z, Lian Y, Huang Y, Chen Y, Chen C, Zhou W, Cai T, Hu J. Proteome-Wide Alterations of Asymmetric Arginine Dimethylation Associated With Pancreatic Ductal Adenocarcinoma Pathogenesis. Front Cell Dev Biol. 2020 Dec 3;8:545934. doi: 10.3389/fcell.2020.545934. PMID: 33344439; PMCID: PMC7744470. 18: Corrêa HL, Neves RVP, Deus LA, Maia BCH, Maya AT, Tzanno-Martins C, Souza MK, Silva JAB, Haro AS, Costa F, Moraes MR, Simões HG, Prestes J, Stone W, Rosa TS. Low-load resistance training with blood flow restriction prevent renal function decline: The role of the redox balance, angiotensin 1-7 and vasopressin✰,✰✰. Physiol Behav. 2021 Mar 1;230:113295. doi: 10.1016/j.physbeh.2020.113295. Epub 2020 Dec 16. PMID: 33340514. 19: Yan J, Kuzhiumparambil U, Bandodkar A, Bandodkar S, Dale RC, Fu S. Cerebrospinal fluid metabolites in tryptophan-kynurenine and nitric oxide pathways: biomarkers for acute neuroinflammation. Dev Med Child Neurol. 2020 Dec 17. doi: 10.1111/dmcn.14774. Epub ahead of print. PMID: 33336374. 20: Nowroozpoor A, Gutterman D, Safdar B. Is microvascular dysfunction a systemic disorder with common biomarkers found in the heart, brain, and kidneys? - A scoping review. Microvasc Res. 2021 Mar;134:104123. doi: 10.1016/j.mvr.2020.104123. Epub 2020 Dec 15. PMID: 33333140.