Synonym
Flopropione; Chlonarin; NSC 97909; NSC97909; NSC-97909; Phloropropionone; Supanate;
IUPAC/Chemical Name
1-(2,4,6-trihydroxyphenyl)propan-1-one
InChi Key
PTHLEKANMPKYDB-UHFFFAOYSA-N
InChi Code
InChI=1S/C9H10O4/c1-2-6(11)9-7(12)3-5(10)4-8(9)13/h3-4,10,12-13H,2H2,1H3
SMILES Code
CCC(c1c(O)cc(O)cc1O)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
182.18
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Ohgaki K. Efficacy of Naftopidil as a Medical Expulsive Therapy in Japanese Men With Ureteral Stones: A Prospective Randomized Controlled Study. J Clin Med Res. 2019 Jul;11(7):495-500. doi: 10.14740/jocmr3843. Epub 2019 Jun 11. PMID: 31236168; PMCID: PMC6575123.
2: Aso Y, Yoshioka S, Kojima S. Relationship between the crystallization rates of amorphous nifedipine, phenobarbital, and flopropione, and their molecular mobility as measured by their enthalpy relaxation and (1)H NMR relaxation times. J Pharm Sci. 2000 Mar;89(3):408-16. doi: 10.1002/(SICI)1520-6017(200003)89:3<408::AID-JPS11>3.0.CO;2-#. PMID: 10707020.
3: Kohjimoto Y, Hagino K, Ogawa T, Inagaki T, Kitamura S, Nishihata M, Iba A, Matsumura N, Hara I. Naftopidil versus flopropione as medical expulsive therapy for distal ureteral stones: results of a randomized, multicenter, double-blind, controlled trial. World J Urol. 2015 Dec;33(12):2125-9. doi: 10.1007/s00345-015-1556-x. Epub 2015 Apr 14. PMID: 25869815.
4: Kondo A, Shimizu K. [Spanate (flopropione), its clinical evaluation for urolithiasis and effects on ureteral peristalsis and blood pressure in dogs]. Hinyokika Kiyo. 1969 Oct;15(10):748-54. Japanese. PMID: 5390817.
5: Bhugra C, Shmeis R, Krill SL, Pikal MJ. Predictions of onset of crystallization from experimental relaxation times I-correlation of molecular mobility from temperatures above the glass transition to temperatures below the glass transition. Pharm Res. 2006 Oct;23(10):2277-90. doi: 10.1007/s11095-006-9079-1. Epub 2006 Aug 24. PMID: 16933094.
