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MedKoo Cat#: 413288 | Name: Corticotropin

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Corticotropin is a polypeptide hormone, also known as adrenocorticotropic hormone (ACTH), synthesized and stored in the anterior pituitary gland. Large amounts of corticotropin are released in response to any form of stress.

Chemical Structure

Corticotropin
Corticotropin
CAS#12427-33-7

Theoretical Analysis

MedKoo Cat#: 413288

Name: Corticotropin

CAS#: 12427-33-7

Chemical Formula: C207H308N56O58S

Exact Mass: 4538.2594

Molecular Weight: 4541.13

Elemental Analysis: C, 54.75; H, 6.84; N, 17.27; O, 20.43; S, 0.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Corticotropin; ACTH; Adrenocorticotrophin
IUPAC/Chemical Name
alpha1-39-Corticotropin (swine), 25-L-aspartic acid-30-L-glutamine
InChi Key
IDLFZVILOHSSID-OVLDLUHVSA-N
InChi Code
InChI=1S/C207H308N56O58S/c1-108(2)89-140(186(302)240-135(69-74-163(279)280)182(298)254-149(204(320)321)94-117-43-20-15-21-44-117)250-193(309)152-54-35-86-262(152)202(318)147(92-116-41-18-14-19-42-116)252-171(287)114(11)230-175(291)132(66-71-160(273)274)234-170(286)113(10)231-191(307)150(105-265)255-183(299)136(70-75-164(281)282)241-190(306)146(98-165(283)284)249-180(296)133(67-72-161(275)276)235-169(285)112(9)229-157(270)101-225-174(290)145(97-156(213)269)251-194(310)153-55-36-87-263(153)203(319)148(93-119-60-64-123(268)65-61-119)253-199(315)167(110(5)6)257-185(301)129(49-26-30-79-210)243-198(314)168(111(7)8)259-196(312)155-57-38-85-261(155)201(317)139(53-34-83-223-207(218)219)244-178(294)130(51-32-81-221-205(214)215)237-177(293)128(48-25-29-78-209)236-176(292)127(47-24-28-77-208)232-158(271)103-227-197(313)166(109(3)4)258-195(311)154-56-37-84-260(154)200(316)138(50-27-31-80-211)233-159(272)102-226-173(289)143(95-120-99-224-126-46-23-22-45-124(120)126)247-179(295)131(52-33-82-222-206(216)217)238-187(303)142(90-115-39-16-13-17-40-115)246-189(305)144(96-121-100-220-107-228-121)248-181(297)134(68-73-162(277)278)239-184(300)137(76-88-322-12)242-192(308)151(106-266)256-188(304)141(245-172(288)125(212)104-264)91-118-58-62-122(267)63-59-118/h13-23,39-46,58-65,99-100,107-114,125,127-155,166-168,224,264-268H,24-38,47-57,66-98,101-106,208-212H2,1-12H3,(H2,213,269)(H,220,228)(H,225,290)(H,226,289)(H,227,313)(H,229,270)(H,230,291)(H,231,307)(H,232,271)(H,233,272)(H,234,286)(H,235,285)(H,236,292)(H,237,293)(H,238,303)(H,239,300)(H,240,302)(H,241,306)(H,242,308)(H,243,314)(H,244,294)(H,245,288)(H,246,305)(H,247,295)(H,248,297)(H,249,296)(H,250,309)(H,251,310)(H,252,287)(H,253,315)(H,254,298)(H,255,299)(H,256,304)(H,257,301)(H,258,311)(H,259,312)(H,273,274)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,320,321)(H4,214,215,221)(H4,216,217,222)(H4,218,219,223)/t112-,113-,114-,125-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,166-,167-,168-/m0/s1
SMILES Code
CSCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc2cnc[nH]2)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N6CCC[C@H]6C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N7CCC[C@H]7C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc8ccc(O)cc8)C(=O)N9CCC[C@H]9C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc%10ccccc%10)C(=O)N%11CCC[C@H]%11C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc%12ccccc%12)C(=O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 4,541.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kutz CF, Dix AL. Repository corticotropin injection in multiple sclerosis: an update. Neurodegener Dis Manag. 2018 Aug;8(4):217-225. doi: 10.2217/nmt-2018-0008. Epub 2018 Jun 5. PMID: 29869572. 2: Schöneshöfer M, Goverde HJ. Corticotropin in human plasma. General considerations. Surv Immunol Res. 1984;3(1):55-63. doi: 10.1007/BF02918598. PMID: 6326236. 3: Garmendia F. Revisión del metabolismo de la corticotrofina [Review of corticotropin metabolism]. Rev Soc Peru Endocrinol. 1966 Jun;3(1):121-8. Spanish. PMID: 4288074. 4: Bories H. Corticotrophine (A.C.T.H.) [Corticotropin (A.C.T.H.)]. Infirm Fr. 1976 May;(175):9-11. French. PMID: 179945. 5: Vergoni AV, Poggioli R, Bertolini A. Corticotropin inhibits food intake in rats. Neuropeptides. 1986 Feb-Mar;7(2):153-8. doi: 10.1016/0143-4179(86)90091-0. PMID: 3010169. 6: CONWAY H, STARK RB. Corticotropin (ACTH) in treatment of keloids. AMA Arch Surg. 1952 Jan;64(1):47-50. doi: 10.1001/archsurg.1952.01260010058006. PMID: 14877398. 7: FREYDBERG LD. The place of corticotropin in the treatment of myasthenia gravis. Ann Intern Med. 1960 Apr;52:806-18. doi: 10.7326/0003-4819-52-4-806. PMID: 13824951. 8: Korkach VI. Vnenadpochechnikovoe deĭstvie kortikotropina (obzor literatury) [Extra-adrenal action of corticotropin (a review of the literature)]. Vrach Delo. 1986 Nov;(11):38-43. Russian. PMID: 3029996. 9: Falk WE, Mahnke MW, Poskanzer DC. Lithium prophylaxis of corticotropin- induced psychosis. JAMA. 1979 Mar 9;241(10):1011-2. PMID: 216818. 10: HARNAGEL EE. Cortisone and corticotropin (ACTH); a review. Calif Med. 1953 Nov;79(5):394-401. PMID: 13106719; PMCID: PMC1521918.