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MedKoo Cat#: 555371 | Name: GJ072

Description:

WARNING: This product is for research use only, not for human or veterinary use.

GJ-072 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent polypeptide.

Chemical Structure

GJ072
GJ072
CAS#943092-47-5

Theoretical Analysis

MedKoo Cat#: 555371

Name: GJ072

CAS#: 943092-47-5

Chemical Formula: C22H18FN5O2S

Exact Mass: 435.1165

Molecular Weight: 435.48

Elemental Analysis: C, 60.68; H, 4.17; F, 4.36; N, 16.08; O, 7.35; S, 7.36

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
GJ-072; GJ 072; GJ072;
IUPAC/Chemical Name
N-(4-fluorophenyl)-2-((4-(3-methoxyphenyl)-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)acetamide
InChi Key
CXIQYWLXCWNKRJ-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H18FN5O2S/c1-30-18-6-4-5-17(13-18)28-21(19-7-2-3-12-24-19)26-27-22(28)31-14-20(29)25-16-10-8-15(23)9-11-16/h2-13H,14H2,1H3,(H,25,29)
SMILES Code
O=C(NC1=CC=C(F)C=C1)CSC2=NN=C(C3=NC=CC=C3)N2C4=CC=CC(OC)=C4
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Chemical-induced read through of premature stop codons might be exploited as a potential treatment strategy for genetic disorders caused by nonsense mutations.

Preparing Stock Solutions

The following data is based on the product molecular weight 435.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Lavin MF. Generating SM(a)RTer compounds for translation termination suppression in A-T and other genetic disorders. Mol Ther. 2013 Sep;21(9):1650-2. doi: 10.1038/mt.2013.177. PubMed PMID: 24008619; PubMed Central PMCID: PMC3776641. 2: Du L, Jung ME, Damoiseaux R, Completo G, Fike F, Ku JM, Nahas S, Piao C, Hu H, Gatti RA. A new series of small molecular weight compounds induce read through of all three types of nonsense mutations in the ATM gene. Mol Ther. 2013 Sep;21(9):1653-60. doi: 10.1038/mt.2013.150. Epub 2013 Jun 18. PubMed PMID: 23774824; PubMed Central PMCID: PMC3776636.