MedKoo Cat#: 561008 | Name: AX15836
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

AX15836 is a highly potent and selective ERK5 inhibitor.

Chemical Structure

AX15836
AX15836
CAS#2035509-96-5

Theoretical Analysis

MedKoo Cat#: 561008

Name: AX15836

CAS#: 2035509-96-5

Chemical Formula: C32H40N8O5S

Exact Mass: 648.2842

Molecular Weight: 648.78

Elemental Analysis: C, 59.24; H, 6.21; N, 17.27; O, 12.33; S, 4.94

Price and Availability

Size Price Availability Quantity
10mg USD 685.00 2 Weeks
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Related CAS #
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Synonym
AX15836; AX 15836; AX-15836
IUPAC/Chemical Name
2-(2-Ethoxy-4-(4-(4-methylpiperazin-1-yl)piperidine-1-carbonyl)phenylamino)-5-methyl-11-(methylsulfonyl)-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one
InChi Key
HTFNVAVTYILUCF-UHFFFAOYSA-N
InChi Code
InChI=1S/C32H40N8O5S/c1-5-45-28-20-22(30(41)39-14-12-23(13-15-39)38-18-16-36(2)17-19-38)10-11-25(28)34-32-33-21-27-29(35-32)40(46(4,43)44)26-9-7-6-8-24(26)31(42)37(27)3/h6-11,20-21,23H,5,12-19H2,1-4H3,(H,33,34,35)
SMILES Code
O=C1C2=CC=CC=C2N(S(=O)(C)=O)C3=NC(NC4=CC=C(C(N5CCC(N6CCN(C)CC6)CC5)=O)C=C4OCC)=NC=C3N1C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 648.78 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Biological Sciences - Cell Biology: ERK5 kinase activity is dispensable for cellular immune response and proliferation Emme C. K. Lin, Christopher M. Amantea, Tyzoon K. Nomanbhoy, Helge Weissig, Junichi Ishiyama, Yi Hu, Shyama Sidique, Bei Li, John W. Kozarich, and Jonathan S. Rosenblum PNAS 2016 ; published ahead of print September 27, 2016, doi:10.1073/pnas.1609019113