MedKoo Cat#: 413228 | Name: Colestipol HCl
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Colestipol HCl is a highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.

Chemical Structure

Colestipol HCl
CAS#37296-80-3 (HCl)

Theoretical Analysis

MedKoo Cat#: 413228

Name: Colestipol HCl

CAS#: 37296-80-3 (HCl)

Chemical Formula: C8H24ClN5

Exact Mass: 0.0000

Molecular Weight: 225.77

Elemental Analysis: C, 42.56; H, 10.72; Cl, 15.70; N, 31.02

Price and Availability

Size Price Availability Quantity
200mg USD 950.00 2 Weeks
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Related CAS #
No Data
Synonym
Colestipol HCl; U26597A; U 26597A; U-26597A
IUPAC/Chemical Name
N1-(2-aminoethyl)-N2-(2-((2-aminoethyl)amino)ethyl)ethane-1,2-diamine hydrochloride
InChi Key
GACQNVJDWUAPFY-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H23N5.ClH/c9-1-3-11-5-7-13-8-6-12-4-2-10;/h11-13H,1-10H2;1H
SMILES Code
NCCNCCNCCNCCN.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 225.77 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Colestipol. 2022 Sep 19. PMID: 30000452. 2: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Colestipol. 2017 Sep 28. PMID: 31643751. 3: Hameed MH, Farzam K. Colestipol. 2023 Jul 2. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 36508523. 4: Camilleri M, Vijayvargiya P. The Role of Bile Acids in Chronic Diarrhea. Am J Gastroenterol. 2020 Oct;115(10):1596-1603. doi: 10.14309/ajg.0000000000000696. PMID: 32558690; PMCID: PMC7541465. 5: Davies NM, Anderson KE. Clinical pharmacokinetics of diclofenac. Therapeutic insights and pitfalls. Clin Pharmacokinet. 1997 Sep;33(3):184-213. doi: 10.2165/00003088-199733030-00003. PMID: 9314611. 6: Nekl KE, Aron DC. Hydrocortisone-colestipol interaction. Ann Pharmacother. 1993 Jul-Aug;27(7-8):980-1. doi: 10.1177/106002809302700734. PMID: 8364291. 7: Sirmans SM, Beck JK, Banh HL, Freeman DA. Colestipol-induced hepatotoxicity. Pharmacotherapy. 2001 Apr;21(4):513-6. doi: 10.1592/phco.21.5.513.34501. PMID: 11310528. 8: Lipid-lowering drugs. Med Lett Drugs Ther. 2022 Sep 19;64(1659):145-152. PMID: 36094548. 9: Lipid-lowering drugs. Med Lett Drugs Ther. 2019 Feb 11;61(1565):17-24. PMID: 30845106. 10: Barkun AN, Love J, Gould M, Pluta H, Steinhart H. Bile acid malabsorption in chronic diarrhea: pathophysiology and treatment. Can J Gastroenterol. 2013 Nov;27(11):653-9. doi: 10.1155/2013/485631. PMID: 24199211; PMCID: PMC3816948. 11: Franco J. Pruritus. Curr Treat Options Gastroenterol. 1999 Dec;2(6):451-456. doi: 10.1007/s11938-999-0048-8. PMID: 11097728. 12: Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS. Colestipol: a review of its pharmacological properties and therapeutic efficacy in patients with hypercholesterolaemia. Drugs. 1980 Mar;19(3):161-80. doi: 10.2165/00003495-198019030-00001. PMID: 6988203. 13: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Antilipemic Agents. 2019 Jun 4. PMID: 31643276. 14: Kane JP, Malloy MJ. Treatment of hypercholesterolemia. Med Clin North Am. 1982 Mar;66(2):537-50. doi: 10.1016/s0025-7125(16)31434-1. PMID: 7040850. 15: Steinmetz KL. Colesevelam hydrochloride. Am J Health Syst Pharm. 2002 May 15;59(10):932-9. doi: 10.1093/ajhp/59.10.932. PMID: 12040732. 16: Ast M, Frishman WH. Bile acid sequestrants. J Clin Pharmacol. 1990 Feb;30(2):99-106. doi: 10.1002/j.1552-4604.1990.tb03447.x. PMID: 2179278. 17: Grundy SM. Treatment of hypercholesterolemia. Am J Clin Nutr. 1977 Jun;30(6):985-92. doi: 10.1093/ajcn/30.6.985. PMID: 326023. 18: Robertson D, Dixon C, Aungst A, McCoy B, Moreo N, Casady L, Maldonado J. Tolerability and efficacy of colestipol hydrochloride for accelerated elimination of teriflunomide. Expert Rev Clin Pharmacol. 2017 Dec;10(12):1403-1407. doi: 10.1080/17512433.2017.1395280. Epub 2017 Nov 2. PMID: 29064296. 19: Kane JP, Havel RJ. Treatment of hypercholesterolemia. Annu Rev Med. 1986;37:427-35. doi: 10.1146/annurev.me.37.020186.002235. PMID: 3518611. 20: Glueck CJ. Colestipol and probucol: treatment of primary and familial hypercholesterolemia and amelioration of atherosclerosis. Ann Intern Med. 1982 Apr;96(4):475-82. doi: 10.7326/0003-4819-96-4-475. PMID: 7039445.